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\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a<\/strong><\/p>\n

\n

        \u51fa\u54c1\uff1a\u79d1\u666e\u4e2d\u56fd<\/p>\n

\u3000\u3000\u5236\u4f5c\uff1a\u5f00\u666e\u4e50\u521b\u5ba2\u56e2\u961f \u5f20\u96e8\u6668<\/p>\n

\u3000\u3000\u76d1\u5236\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u8ba1\u7b97\u673a\u7f51\u7edc\u4fe1\u606f\u4e2d\u5fc3<\/p>\n

\u3000\u30002015\u5e7410\u6708\u521d\uff0c\u4e16\u754c\u9876\u7ea7\u79d1\u5b66\u520a\u7269\u300a\u79d1\u5b66\u300b\u7684\u65b0\u4e00\u671f\u53d1\u8868\u4e86\u4e00\u7bc7\u91cd\u8981\u7684\u7814\u7a76\u8bba\u6587\u3002\u8bba\u6587\u4f5c\u8005\u2014\u2014\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u79d1\u5b66\u5bb6\u4e54\u6cbb\u3002\u5f7b\u5947\uff08George Church\uff09\u901a\u8fc7\u4f7f\u7528CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6210\u529f\u6291\u5236\u4e86\u732a\u4f53\u5185\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08PERV\uff09\u7684\u57fa\u56e0\uff0c\u4f7f\u732a\u6765\u6e90\u5f02\u79cd\u5668\u5b98\u79fb\u690d\u7684\u7814\u7a76\u8fdb\u7a0b\u5927\u5927\u63a8\u8fdb\u3002<\/p>\n

\u3000\u3000\u5e7f\u5927\u4eba\u6c11\u7fa4\u4f17\u7eb7\u7eb7\u8868\u793a\uff0c\u8fd9\u65b0\u95fb\u751f\u8bcd\u6709\u70b9\u591a\u554a\uff0c\u80fd\u8bf4\u4eba\u8bdd\u4e48\uff1f<\/p>\n

\u3000\u3000\u597d\uff0c\u54b1\u4eec\u4e00\u4e2a\u4e00\u4e2a\u63b0\u5f00\u8bf4\uff0c\u5148\u6765\u770b\u770b\u6bd4\u8f83\u5bb9\u6613\u7406\u89e3\u7684\u201c\u5f02\u79cd\u5668\u5b98\u79fb\u690d\u201d\u3002<\/p>\n

\u3000\u3000\u4ec0\u4e48\u662f\u5f02\u79cd\u5668\u5b98\u79fb\u690d\uff1f<\/b><\/p>\n

\u3000\u3000\u5f02\u79cd\u79fb\u690d\uff0c\u662f\u5c06\u67d0\u4e00\u79cd\u5c5e\u4e2a\u4f53\u7684\u5668\u5b98\u6216\u7ec4\u7ec7\u79fb\u690d\u5230\u53e6\u4e00\u79cd\u5c5e\u4e2a\u4f53\u7684\u67d0\u4e00\u90e8\u4f4d\u3002\u4f17\u6240\u5468\u77e5\uff0c\u4eba\u7c7b\u6765\u6e90\u7684\u5668\u5b98\u4f9b\u5e94\u5904\u4e8e\u4e25\u91cd\u7684\u201c\u4f9b\u4e0d\u5e94\u6c42\u201d\u72b6\u6001\uff0c\u56e0\u4f20\u7edf\u89c2\u5ff5\u5f71\u54cd\uff0c\u6211\u56fd\u5668\u5b98\u6350\u732e\u7387\u5728\u4e3b\u8981\u5927\u56fd\u4e2d\u66f4\u662f\u51fa\u4e86\u540d\u7684\u4f4e\uff0c\u4f7f\u5f97\u79fb\u690d\u5668\u5b98\u77ed\u7f3a\u7684\u95ee\u9898\u96ea\u4e0a\u52a0\u971c\uff0c\u5e76\u8fdb\u4e00\u6b65\u5bfc\u81f4\u4e86\u5668\u5b98\u9ed1\u5e02\u4e70\u5356\u7b49\u5404\u79cd\u793e\u4f1a\u95ee\u9898\u3002\u4f46\u662f\uff0c\u76ee\u524d\uff0c\u5668\u5b98\u79fb\u690d\u4f9d\u7136\u662f\u5f88\u591a\u6076\u6027\u75be\u75c5\u7684\u6700\u7ec8\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

\u3000\u3000\u9762\u5bf9\u8fd9\u79cd\u56f0\u5883\uff0c\u6709\u806a\u660e\u4eba\u51fa\u4e86\u4e2a\u597d\u4e3b\u610f\uff1a\u65e2\u7136\u4eba\u7684\u5668\u5b98\u4e0d\u597d\u627e\uff0c\u80fd\u5426\u7528\u5176\u5b83\u52a8\u7269\u7684\u5668\u5b98\u66ff\u4ee3\u4e00\u4e0b\uff1f<\/p>\n

\u3000\u3000\u8fd9\u5e76\u975e\u5929\u65b9\u591c\u8c2d\u3002<\/p>\n

\u3000\u3000\u987b\u77e5\uff0c\u5730\u7403\u6240\u6709\u751f\u7269\u5728\u8fdb\u5316\u4e0a\u90fd\u672c\u51fa\u4e00\u5bb6\uff0c\u5728\u5f88\u591a\u57fa\u672c\u751f\u7406\u3001\u751f\u5316\u548c\u9057\u4f20\u673a\u5236\u4e0a\u90fd\u6709\u7740\u4e0d\u540c\u7a0b\u5ea6\u7684\u4e00\u81f4\u6027\u3002\u800c\u5728\u4eba\u7c7b\u6240\u5c5e\u7684\u54fa\u4e73\u7eb2\u5185\u90e8\uff0c\u4e0d\u540c\u7269\u79cd\u95f4\u5f88\u591a\u5668\u5b98\u7684\u529f\u80fd\u548c\u7ed3\u6784\u5e76\u65e0\u672c\u8d28\u5dee\u5f02\uff0c\u57fa\u672c\u8fd0\u884c\u65b9\u5f0f\u5927\u540c\u5c0f\u5f02\u3002\u8fd9\u6837\u4e00\u6765\uff0c\u8de8\u7269\u79cd\u5668\u5b98\u79fb\u690d\u4ece\u751f\u7406\u5b66\u548c\u89e3\u5256\u5b66\u4e0a\u770b\u4f3c\u4e4e\u5e76\u65e0\u4e0d\u53ef\u3002<\/p>\n

\u3000\u3000\u4f46\u5668\u5b98\u7684\u5177\u4f53\u6027\u80fd\u548c\u5c3a\u5bf8\u8fd8\u662f\u9700\u8981\u8003\u8651\u7684\u3002\u7075\u957f\u7c7b\u540c\u80de\u867d\u7136\u548c\u4eba\u7c7b\u6700\u4e3a\u63a5\u8fd1\uff0c\u4f46\u5927\u591a\u6570\u6210\u5458\u4f53\u578b\u592a\u5c0f\uff0c\u5668\u5b98\u6839\u672c\u65e0\u6cd5\u627f\u62c5\u4eba\u4f53\u4ee3\u8c22\u7684\u9700\u8981\u3002\u800c\u9ed1\u7329\u7329\u3001\u502d\u9ed1\u7329\u7329\u3001\u5927\u7329\u7329\u3001\u7ea2\u6bdb\u7329\u7329\u7b49\u5927\u578b\u7c7b\u4eba\u733f\u53c8\u90fd\u662f\u6fd2\u5371\u7684\u7a00\u6709\u52a8\u7269\uff0c\u5730\u4f4d\u5c0a\u8d35\u6839\u672c\u52a8\u4e0d\u5f97\u3002<\/p>\n

\u3000\u3000\u65e2\u7136\u5b59\u7334\u5b50\u8fd9\u4e2a\u201c\u5927\u5e08\u5144\u201d\u6307\u671b\u4e0d\u4e0a\uff0c\u90a3\u5c31\u53ea\u597d\u70e6\u52b3\u201c\u4e8c\u5e08\u5144\u201d\u732a\u516b\u6212\u727a\u7272\u4e00\u4e0b\u4e86\u3002<\/p>\n


<\/p>\n

\u56fe1 \u732a\u7684\u5168\u8eab\u90fd\u662f\u5b9d\uff0c\u4e0d\u4f46\u80fd\u5403\uff0c\u8fd8\u53ef\u80fd\u6551\u547d<\/center>

\u3000\u3000\u867d\u7136\u5728\u5206\u7c7b\u4e0a\uff0c\u732a\u548c\u4eba\u4e00\u4e2a\u662f\u5076\u8e44\u76ee\u4e00\u4e2a\u662f\u7075\u957f\u76ee\uff0c\u76f8\u5dee\u633a\u8fdc\uff0c\u4f46\u4ece\u4f53\u578b\u3001\u98df\u6027\u3001\u4ee3\u8c22\u6c34\u5e73\u8fd9\u4e9b\u5916\u5728\u6307\u6807\u770b\uff0c\u5374\u548c\u4eba\u7c7b\u5927\u4f53\u63a5\u8fd1\uff0c\u732a\u7684\u4e00\u4e9b\u5668\u5b98\u4ece\u201c\u6027\u80fd\u53c2\u6570\u201d\u4e0a\u770b\u548c\u4eba\u7c7b\u57fa\u672c\u5904\u4e8e\u540c\u4e00\u6863\u6b21\u3002\u52a0\u4e4b\u732a\u4fbf\u4e8e\u5b9a\u5411\u80b2\u79cd\u548c\u5927\u89c4\u6a21\u7e41\u6b96\uff0c\u663e\u7136\u662f\u4e0d\u9519\u7684\u6f5c\u5728\u5668\u5b98\u79fb\u690d\u6765\u6e90\u3002<\/span>

\u3000\u3000\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4e5f\u4f9d\u7136\u53ea\u662f\u201c\u6f5c\u5728\u201d\u6765\u6e90\uff0c\u95ee\u9898\u51fa\u5728\u54ea\u91cc\u5462\uff1f<\/span>

\u3000\u3000\u201c\u6f5c\u5728\u201d\u7684\u5668\u5b98\u79fb\u690d\uff0c\u4e3a\u4f55\u8fd8\u672a\u201c\u8f6c\u6b63\u201d\uff1f<\/b>


<\/p>\n

\u56fe2 \u6700\u7b80\u5355\u7684\u5668\u5b98\u79fb\u690d\u6297\u539f\u914d\u578b\u2014\u2014\u4ea4\u53c9\u914d\u8840\u8bd5\u9a8c<\/center>

\u3000\u3000\u7b54\u6848\u5c31\u5728\u66f4\u52a0\u5fae\u89c2\u7684\u7ec6\u80de\u548c\u5206\u5b50\u5c42\u9762\u3002<\/span>

\u3000\u3000\u5373\u4fbf\u5bf9\u5668\u5b98\u79fb\u690d\u4e86\u89e3\u4ec5\u9650\u4e8e\u7535\u89c6\u5267\u91cc\u767d\u8840\u75c5\u201c\u6362\u8840\u201d\u7684\u4eba\u4e5f\u77e5\u9053\uff0c\u5668\u5b98\u79fb\u690d\u6700\u5927\u7684\u95e8\u69db\u5c31\u662f\u201c\u6297\u539f\u914d\u578b\u201d\u3002<\/span>

\u3000\u3000\u6297\u539f\u914d\u578b\u7684\u672c\u8d28\uff0c\u5c31\u662f\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u5bf9\u5916\u6765\u5f02\u7269\u7684\u6392\u65a5\u4f5c\u7528\u3002\u5728\u5e73\u65f6\uff0c\u8fd9\u79cd\u673a\u80fd\u662f\u634d\u536b\u673a\u4f53\u5065\u5eb7\u7684\u94a2\u94c1\u957f\u57ce\uff1b\u4f46\u5728\u5668\u5b98\u79fb\u690d\u65f6\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u6392\u65a5\u653b\u51fb\u53ef\u4ee5\u8ba9\u5916\u6765\u5668\u5b98\u5728\u51e0\u5206\u949f\u5185\u5c31\u4e27\u5931\u529f\u80fd\u3002\u800c\u51b3\u5b9a\u514d\u75ab\u7cfb\u7edf\u5224\u65ad\u201c\u4eb2\u758f\u8fdc\u8fd1\u201d\u7684\u4e3b\u8981\u6807\u51c6\uff0c\u5219\u662f\u5916\u6765\u7ec6\u80de\u8868\u9762\u6297\u539f\u7684\u79cd\u7c7b\uff0c\u548c\u673a\u4f53\u672c\u8eab\u8868\u9762\u6297\u539f\u76f8\u4f3c\u5ea6\u8d8a\u9ad8\u8d8a\u5b89\u5168\u3002<\/span>

\u3000\u3000\u5b9e\u9645\u4e0a\uff0c\u5927\u5bb6\u719f\u6089\u7684\u8f93\u8840\u65f6\u7684\u201c\u8840\u578b\u914d\u5bf9\u201d\u5c31\u662f\u4e00\u79cd\u6781\u5176\u7b80\u5355\u7684\u6297\u539f\u914d\u578b\uff0c\u4e00\u822c\u53ea\u7528\u8003\u8651ABO\u548cRh\u7b49\u5c11\u6570\u51e0\u79cd\u7ea2\u7ec6\u80de\u8868\u9762\u6297\u539f\u5373\u53ef\u3002\u800c\u79fb\u690d\u5927\u578b\u5668\u5b98\u65f6\uff0c\u56e0\u4e3a\u6d89\u53ca\u7ec6\u80de\u79cd\u7c7b\u7e41\u591a\uff0c\u914d\u578b\u4f1a\u53d8\u5f97\u6781\u5176\u590d\u6742\uff0c\u60f3\u5728\u832b\u832b\u4eba\u6d77\u4e2d\u627e\u5230\u7b26\u5408\u6761\u4ef6\u7684\u6350\u732e\u8005\uff0c\u65e0\u5f02\u4e8e\u5927\u6d77\u635e\u9488\u3002<\/span>

\u3000\u3000\u5f53\u7136\uff0c\u8fd9\u4e9b\u95ee\u9898\u53ef\u4ee5\u901a\u8fc7\u4e13\u95e8\u7684\u514d\u75ab\u6291\u5236\u5242\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u8fdb\u884c\u7f13\u89e3\uff0c\u4f46\u732a\u548c\u4eba\u7684\u5dee\u5f02\u6bd5\u7adf\u4e0d\u662f\u4eba\u4e0e\u4eba\u4e4b\u95f4\u53ef\u6bd4\u7684\uff0c\u5355\u9760\u514d\u75ab\u6291\u5236\u5242\u96be\u4ee5\u76f4\u63a5\u5b8c\u6210\u8fd9\u6837\u7684\u8de8\u7269\u79cd\u79fb\u690d\u3002<\/span>

\u3000\u3000\u5230\u73b0\u5728\u4e3a\u6b62\uff0c\u5f02\u79cd\u5668\u5b98\u79fb\u690d\u7684\u514d\u75ab\u6392\u65a5\u90fd\u662f\u4e2a\u5f88\u68d8\u624b\u7684\u8bfe\u9898\u3002\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\uff0c\u57f9\u80b2\u6ca1\u6709\u514d\u75ab\u8bc6\u522b\u969c\u788d\u3001\u53ef\u4ee5\u968f\u610f\u5411\u4efb\u4f55\u514d\u75ab\u80cc\u666f\u60a3\u8005\u63d0\u4f9b\u5668\u5b98\u7684\u201c\u4e07\u80fd\u732a\u201d\u4e00\u76f4\u662f\u751f\u547d\u79d1\u5b66\u548c\u533b\u5b66\u754c\u7684\u4e00\u5927\u68a6\u60f3\u3002<\/span>

\u3000\u3000\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0c\u57f9\u80b2\u201c\u4e07\u80fd\u732a\u201d\u7684\u963b\u788d<\/b>

<\/p>\n

\u56fe3 \u75c5\u6bd2\u611f\u67d3\u4fb5\u88ad\u7ec6\u80de\u8fc7\u7a0b<\/center>

\u3000\u3000\u800c\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u79d1\u5b66\u5bb6\u8fd8\u53d1\u73b0\u4e86\u53e6\u4e00\u4e2a\u66f4\u5934\u75bc\u7684\u96be\u70b9\uff0c\u5c31\u662f\u4e0a\u6587\u63d0\u5230\u7684\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08PERV\uff09\u3002<\/span>

\u3000\u3000\u4ec0\u4e48\u662f\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\u5462\uff1f<\/b>

\u3000\u3000\u6240\u6709\u75c5\u6bd2\uff0c\u5176\u62ff\u624b\u7edd\u6d3b\u90fd\u662f\u611f\u67d3\u5bbf\u4e3b\u7ec6\u80de\uff0c\u7528\u5404\u79cd\u65b9\u5f0f\u5c06\u81ea\u5df1\u7684\u57fa\u56e0\u7247\u6bb5\u63d2\u5165\u5230\u5bbf\u4e3b\u7ec6\u80de\u7684\u57fa\u56e0\u4e2d\uff0c\u518d\u4ee5\u81ea\u5df1\u7684\u57fa\u56e0\u4e3a\u84dd\u672c\u3001\u5229\u7528\u5bbf\u4e3b\u7ec6\u80de\u6765\u590d\u5236\u81ea\u5df1\u611f\u67d3\u66f4\u591a\u7ec6\u80de\uff0c\u5982\u6b64\u5faa\u73af\u3002<\/span>

\u3000\u3000\u5927\u5bb6\u719f\u77e5\u7684\u611f\u5192\u75c5\u6bd2\uff0c\u5c31\u662f\u8fd9\u6837\u6298\u817e\u4e0a\u547c\u5438\u9053\u7684\uff0c\u4e2d\u62db\u8005\u81ea\u7136\u96be\u514d\u6d95\u6cea\u6a2a\u6d41\u3002<\/span>

\u3000\u3000\u4f46\u6709\u4e9b\u75c5\u6bd2\u5728\u611f\u5192\u75c5\u6bd2\u4ee3\u8868\u7684\u201c\u7c97\u653e\u5f0f\u201d\u6269\u589e\u611f\u67d3\u65b9\u5f0f\u4e4b\u5916\u5f00\u8f9f\u4e86\u4e00\u6761\u66f4\u52a0\u201c\u6e29\u548c\u201d\u7684\u65b0\u8def\u5b50\u3002<\/span>

\u3000\u3000\u5b83\u4eec\u5c06\u81ea\u5df1\u7684\u57fa\u56e0\u63d2\u5165\u5bbf\u4e3b\u7ec6\u80de\u540e\u5c31\u4e0d\u518d\u8f7b\u4e3e\u5984\u52a8\uff0c\u800c\u662f\u4f4e\u8c03\u5730\u642d\u7740\u5bbf\u4e3b\u7ec6\u80de\u5206\u88c2\u65f6\u57fa\u56e0\u590d\u5236\u7684\u201c\u987a\u98ce\u8f66\u201d\u8fde\u5e26\u590d\u5236\uff0c\u53ea\u5728\u4e00\u4e9b\u5fc5\u8981\u65f6\u523b\u624d\u4ee5\u5b8c\u6574\u75c5\u6bd2\u9897\u7c92\u7684\u72b6\u6001\u51fa\u73b0\u3002\u663e\u7136\uff0c\u8fd9\u79cd\u65b9\u5f0f\u5bf9\u5bbf\u4e3b\u5371\u5bb3\u66f4\u5c0f\uff0c\u867d\u7136\u4e0d\u5982\u7c97\u653e\u5f0f\u90a3\u6837\u7206\u53d1\u8fc5\u901f\uff0c\u4f46\u80dc\u5728\u7ec6\u6c34\u957f\u6d41\uff0c\u5c5e\u4e8e\u66f4\u52a0\u7a33\u5b9a\u7684\u201c\u957f\u7ebf\u6295\u8d44\u201d\u3002<\/span>

\u3000\u3000\u82e5\u662f\u4e00\u822c\u7684\u60c5\u51b5\uff0c\u8fd9\u4e9b\u201c\u6e29\u548c\u201d\u75c5\u6bd2\u4e5f\u4e0d\u8fc7\u611f\u67d3\u673a\u4f53\u5185\u5343\u4ebf\u7ec6\u80de\u7684\u6781\u5c11\u6570\uff0c\u6700\u7ec8\u4e5f\u4f1a\u968f\u7740\u611f\u67d3\u4e2a\u4f53\u7684\u5bff\u7ec8\u6b63\u5bdd\u800c\u6811\u5012\u7322\u72f2\u6563\u3002\u4f46\u82e5\u662f\u8fd9\u75c5\u6bd2\u78b0\u5de7\u611f\u67d3\u4e86\u751f\u6b96\u7ec6\u80de\u751a\u81f3\u53d7\u7cbe\u5375\uff0c\u9634\u5dee\u9633\u9519\u987a\u5229\u53d1\u80b2\u4e3a\u4e00\u4e2a\u5b8c\u6574\u7684\u4e2a\u4f53\uff0c\u90a3\u4e48\u8be5\u4e2a\u4f53\u5185\u6bcf\u4e00\u4e2a\u7ec6\u80de\u90fd\u6709\u5f53\u521d\u75c5\u6bd2\u63d2\u5165\u7684\u57fa\u56e0\u3002\u82e5\u6709\u75c5\u6bd2\u57fa\u56e0\u7684\u4e2a\u4f53\u5065\u5eb7\u6210\u957f\u5e76\u7e41\u6b96\u4e0b\u53bb\uff0c\u90a3\u6700\u7ec8\u5c31\u80fd\u5f62\u6210\u4e00\u4e2a\u5168\u4f53\u5148\u5929\u643a\u5e26\u75c5\u6bd2\u57fa\u56e0\u7684\u79cd\u7fa4\u751a\u81f3\u7269\u79cd\uff01<\/span>

\u3000\u3000\u8fd9\u79cd\u65e0\u6bd4\u8179\u9ed1\u7684\u6218\u7565\u6f5c\u4f0f\u624d\u662f\u6e29\u548c\u578b\u75c5\u6bd2\u771f\u6b63\u7684\u6740\u624b\u950f\uff0c\u653e\u957f\u7ebf\u81ea\u7136\u662f\u4e3a\u4e86\u9493\u5927\u9c7c\u3002\u6b64\u65f6\uff0c\u8fd9\u4e9b\u75c5\u6bd2\u5df2\u7ecf\u53ef\u4ee5\u88ab\u79f0\u4e3a\u201c\u5185\u6e90\u6027\u75c5\u6bd2\u201d\uff0c\u6210\u4e3a\u8be5\u7269\u79cd\u57fa\u56e0\u5e93\u4e2d\u5185\u81ea\u7136\u5b58\u5728\u7684\u4e00\u90e8\u5206\uff0c\u548c\u5bbf\u4e3b\u4e00\u8363\u4ff1\u8363\u4e00\u635f\u4ff1\u635f\u3002<\/span>

\u3000\u3000\u800c\u79d1\u5b66\u5bb6\u6a21\u62df\u8fd9\u79cd\u65b9\u5f0f\uff0c\u901a\u8fc7\u4eba\u5de5\u6539\u9020\u7684\u75c5\u6bd2\u6216\u8005\u6e38\u79bb\u57fa\u56e0\u7247\u6bb5\u5c06\u5404\u79cd\u57fa\u56e0\u8f6c\u5165\u7ec6\u80de\uff0c\u4ece\u800c\u4eba\u4e3a\u5236\u9020\u5185\u542b\u7279\u5b9a\u5916\u6765\u57fa\u56e0\u7684\u65b0\u54c1\u79cd\uff0c\u8fd9\u5c31\u662f\u8f6c\u57fa\u56e0\u6280\u672f\u3002\u65f6\u4e0b\u4e89\u8bba\u6cb8\u6cb8\u626c\u626c\u7684\u201c\u8f6c\u57fa\u56e0\u4f5c\u7269\u201d\u4fbf\u662f\u5176\u5178\u578b\u5e94\u7528\u3002<\/span>

\u3000\u3000\u4f46\u66f4\u90aa\u4e4e\u7684\u7ed3\u679c\u5374\u5728\u540e\u9762\u2014\u2014\u5305\u62ec\u4eba\u7c7b\u5728\u5185\u7684\u5f88\u591a\u7269\u79cd\u90fd\u88ab\u5185\u6e90\u6027\u75c5\u6bd2\u201c\u6f5c\u4f0f\u201d\u4e86\uff01<\/span>

\u3000\u3000\u6ca1\u9519\uff0c\u6211\u4eec\u90fd\u662f\u5929\u7136\u7684\u8f6c\u57fa\u56e0\u751f\u7269\uff01<\/span>

\u3000\u3000\u7ecf\u8fc7\u7ec6\u81f4\u7814\u7a76\uff0c\u79d1\u5b66\u5bb6\u53d1\u73b0\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u6709\u9ad8\u8fbe8%\u5de6\u53f3\u7684\u57fa\u56e0\u90fd\u662f\u6e90\u81ea\u75c5\u6bd2\u7684\u201c\u79fb\u6c11\u201d\uff0c\u800c\u4e14\u4e0d\u5c11\u90fd\u5728\u673a\u4f53\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff0c\u7edd\u975e\u201c\u8e6d\u5403\u8e6d\u559d\u201d\u7684\u65e0\u80fd\u4e4b\u8f88\u3002<\/span>

\u3000\u3000\u4eca\u5e744\u6708\u65af\u5766\u798f\u5927\u5b66\u7684\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u5185\u6e90\u6027\u75c5\u6bd2\u5728\u80da\u80ce\u65e9\u671f\u53d1\u80b2\u7684\u5173\u952e\u7684\u65f6\u671f\u53ef\u80fd\u663e\u8457\u5f71\u54cd\u4e86\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u8fdb\u4e00\u6b65\u5206\u88c2\u53d1\u80b2\uff0c\u5bf9\u4eba\u7c7b\u53d1\u80b2\u6709\u7740\u91cd\u5927\u610f\u4e49\u3002<\/span>

\u3000\u3000\u540c\u4e3a\u54fa\u4e73\u7c7b\u7684\u201c\u4e8c\u5e08\u5144\u201d\u4e5f\u6ca1\u80fd\u5e78\u514d\u3002<\/span>

\u3000\u3000\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08PERV\uff09\u5c31\u662f\u4e00\u79cd\u5728\u732a\u4f53\u5185\u6b63\u5e38\u5b58\u5728\u7684\u75c5\u6bd2\u3002\u800c\u4e14\u548c\u4eba\u7c7b\u7684\u60c5\u51b5\u4e00\u6837\uff0c\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\u7684\u57fa\u56e0\u6df1\u6df1\u6839\u690d\u4e8e\u732a\u7684\u79cd\u7fa4\u57fa\u56e0\u5e93\u4e2d\uff0c\u5e76\u53ef\u80fd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u800c\u65e0\u6cd5\u901a\u8fc7\u5bf9\u5668\u5b98\u6216\u6574\u732a\u8fdb\u884c\u5e38\u89c4\u5904\u7406\u6765\u7b80\u5355\u53bb\u9664\u3002<\/span>

\u3000\u3000\u8fdb\u4e00\u6b65\u7684\u79fb\u690d\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u8fd9\u79cd\u75c5\u6bd2\u901a\u8fc7\u5668\u5b98\u79fb\u690d\u8fdb\u5165\u5176\u4ed6\u5b9e\u9a8c\u52a8\u7269\u4f53\u5185\u540e\u5bf9\u63a5\u53d7\u79fb\u690d\u8005\u90fd\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u635f\u5bb3\u3002\u5bf9\u4e8e\u4eba\u7c7b\uff0c\u867d\u7136\u6682\u65f6\u8fd8\u4e0d\u53ef\u80fd\u6709\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4f46\u98ce\u9669\u4f9d\u7136\u9634\u4e91\u4e0d\u6563\u2014\u2014\u732a\u5668\u5b98\u4e2d\u7684\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08PERV\uff09\u5728\u79fb\u690d\u5165\u4eba\u4f53\u540e\u53ef\u80fd\u4f1a\u635f\u5bb3\u5065\u5eb7\u3002<\/span>

\u3000\u3000\u8fd9\u4e0b\u9ebb\u70e6\u4e86\u3002<\/span>

\u3000\u3000\u65e2\u7136\u5982\u6b64\uff0c\u90a3\u80fd\u4e0d\u80fd\u7528\u57fa\u56e0\u5de5\u7a0b\u7684\u624b\u6bb5\u201c\u4ee5\u5f7c\u4e4b\u9053\u8fd8\u6cbb\u5176\u4eba\u4e4b\u8eab\u201d\u5462\uff1f<\/span>

\u3000\u3000CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u7cbe\u786e\u6253\u51fbPERV<\/b>

\u3000\u3000\u79d1\u7814\u4eba\u5458\u5f53\u7136\u8bd5\u8fc7\u5404\u79cd\u65b9\u6cd5\uff0c\u4f46\u5948\u4f55\u75c5\u6bd2\u57fa\u56e0\u5e7f\u6cdb\u590d\u5236\u5728\u57fa\u56e0\u5e93\u7684\u5404\u4e2a\u5730\u65b9\uff0c\u5c06\u5176\u4e00\u80a1\u8111\u201c\u5220\u9664\u201d\u5bb9\u6613\u4f24\u53ca\u65e0\u8f9c\uff0c\u5bf9\u4e8e\u6574\u4e2a\u57fa\u56e0\u5e93\u6765\u8bf4\uff0c\u4e5f\u662f\u4f24\u7b4b\u52a8\u9aa8\u3002\u6b64\u5916\uff0c\u4f20\u7edf\u7684\u57fa\u56e0\u6572\u9664\u65b9\u5f0f\u6b65\u9aa4\u590d\u6742\uff0c\u9700\u8981\u65f6\u95f4\u8f83\u957f\uff0c\u6548\u7387\u4e5f\u4e0d\u591f\u9ad8\u3002\u79d1\u7814\u754c\u6b64\u65f6\u6025\u9700\u4e00\u79cd\u80fd\u591f\u7cbe\u786e\u4fbf\u6377\u7f16\u8f91\u57fa\u56e0\u7684\u65b9\u6cd5\u3002<\/span>

\u3000\u3000\u968f\u7740\u73b0\u5728\u6700\u597d\u7528\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672fCRISPR\/Cas9\u7684\u51fa\u73b0\uff0c\u4e00\u5207\u6709\u4e86\u8f6c\u673a\u3002<\/span>

\u3000\u3000CRISPR\/Cas9\u6280\u672f\u7b80\u5355\u8bf4\u6765\uff0c\u5c31\u662f\u8ba9\u62e5\u6709\u526a\u5207DNA\u94fe\u6761\u80fd\u529b\u7684Cas9\u5185\u5207\u9176\u5728\u5bfc\u5411RNA\u7247\u6bb5\u7684\u6307\u5f15\u4e0b\u5bf9\u7279\u5b9a\u4f4d\u7f6e\u7684\u57fa\u56e0\u7247\u6bb5\u8fdb\u884c\u7cbe\u786e\u5207\u5272\uff0c\u4ece\u800c\u4eba\u4e3a\u5236\u9020\u57fa\u56e0\u7684\u7a81\u53d8\u751a\u81f3\u5931\u6d3b\uff0c\u4e4b\u540e\u8fd8\u80fd\u5728\u7a7a\u7f3a\u5904\u52a0\u5165\u65b0\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u4eba\u4e3a\u7f16\u8f91\u4fee\u6539\u57fa\u56e0\u5e8f\u5217\u3002\u800c\u4e14\u8be5\u65b9\u6cd5\u64cd\u4f5c\u66f4\u52a0\u7b80\u4fbf\u5feb\u6377\uff0c\u6210\u529f\u7387\u4e5f\u66f4\u9ad8\uff0c\u53ef\u4ee5\u8bf4\u662f\u6574\u4e2a\u57fa\u56e0\u5de5\u7a0b\u754c\u7684\u65b0\u9510\u6280\u672f\u3002<\/span>

\u3000\u3000\u6709\u4e86\u8fd9\u6837\u4e00\u4e2a\u7075\u6d3b\u5feb\u901f\u3001\u53ef\u589e\u53ef\u51cf\u7684\u57fa\u56e0\u7f16\u8f91\u795e\u5668\uff0c\u79d1\u5b66\u5bb6\u7ec8\u4e8e\u628a\u76ee\u5149\u7784\u5411\u4e86\u4e00\u76f4\u770b\u4e0d\u987a\u773c\u7684\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\u3002<\/span>

\u3000\u3000\u6700\u7ec8\uff0c\u54c8\u4f5b\u5927\u5b66\u7684\u7814\u7a76\u8005\u5c06\u76ee\u6807\u9501\u5b9a\u5728\u4e00\u4e2a\u6709\u5173\u9006\u8f6c\u5f55\u75c5\u6bd2\u4fb5\u67d3\u7ec6\u80de\u7684\u5173\u952e\u57fa\u56e0\u4e0a\u3002\u5982\u679c\u8fd9\u4e2a\u57fa\u56e0\u7f3a\u5931\uff0c\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\u5c31\u65e0\u6cd5\u518d\u611f\u67d3\u63a5\u53d7\u79fb\u690d\u673a\u4f53\u7684\u7ec6\u80de\u4e86\u3002<\/span>

\u3000\u3000\u9501\u5b9a\u5177\u4f53\u57fa\u56e0\u4e4b\u540e\uff0c\u5728CRISPR\/Cas9\u6280\u672f\u7684\u5e7f\u6cdb\u7cbe\u786e\u6253\u51fb\u4e0b\uff0c\u8fd9\u4e2a\u5728\u732a\u57fa\u56e0\u5e93\u5185\u590d\u5236\u6709\u5927\u91cf\u5907\u4efd\u7684\u75c5\u6bd2\u57fa\u56e0\u7ec8\u4e8e\u88ab\u5168\u9762\u6e05\u527f\u5e72\u51c0\uff0c\u75c5\u6bd2\u7684\u611f\u67d3\u80fd\u529b\u56e0\u6b64\u5143\u6c14\u5927\u4f24\uff0c\u51e0\u4e4e\u4e0d\u518d\u5177\u6709\u4f20\u67d3\u80fd\u529b\uff0c\u5bf9\u4eba\u4f53\u4e5f\u5c31\u8c08\u4e0d\u4e0a\u4ec0\u4e48\u635f\u5bb3\u4e86\u3002<\/span>

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