{"id":13839,"date":"2019-12-02T00:00:00","date_gmt":"2019-12-01T16:00:00","guid":{"rendered":"http:\/\/15.134.89.131\/archive\/2019\/12\/02\/nature%ef%bc%9a%e6%9c%80%e5%bc%ba%e7%99%8c%e5%9f%ba%e5%9b%a0%e6%89%be%e5%88%b0%e4%ba%86%ef%bc%8c%e5%b1%85%e7%84%b6%e4%b8%8d%e5%9c%a8%e6%9f%93%e8%89%b2%e4%bd%93%e4%b8%8a-%e5%8d%8e%e4%ba%ba%e9%a2%86\/"},"modified":"2019-12-02T00:00:00","modified_gmt":"2019-12-01T16:00:00","slug":"nature%ef%bc%9a%e6%9c%80%e5%bc%ba%e7%99%8c%e5%9f%ba%e5%9b%a0%e6%89%be%e5%88%b0%e4%ba%86%ef%bc%8c%e5%b1%85%e7%84%b6%e4%b8%8d%e5%9c%a8%e6%9f%93%e8%89%b2%e4%bd%93%e4%b8%8a-%e5%8d%8e%e4%ba%ba%e9%a2%86","status":"publish","type":"post","link":"http:\/\/15.134.89.131\/archive\/?p=13839","title":{"rendered":"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76"},"content":{"rendered":"<p style=\"color: #666; font-size: 14px; margin-bottom: 15px;\">\ud83d\udc49 <strong>\u672c\u6587\u4f5c\u8005\uff1a<\/strong><\/p>\n<hr style=\"border: 0; border-top: 1px dashed #ddd; margin-bottom: 20px;\" \/>\n<p><font>\u764c\u75c7\u96be\u6cbb\uff0c\u7f6a\u9b41\u7978\u9996\u7adf\u7136\u662f\u4f60\uff01<\/font><\/p>\n<p><font>\u5728<\/font><b>\u764c\u75c7\u6cbb\u7597<\/b><font>\u9886\u57df\uff0c\u66fe\u7ecf\u5b58\u5728\u8fc7\u4e09\u6b21\u9769\u547d\uff1a<\/font><\/p>\n<p><font>\u7b2c\u4e00\u6b21\u9769\u547d\uff1a\u5316\u7597\uff1b\u7b2c\u4e8c\u6b21\u9769\u547d\uff1a\u9776\u5411\u7597\u6cd5\uff1b\u7b2c\u4e09\u6b21\u9769\u547d\uff1a\u514d\u75ab\u7597\u6cd5\u3002<\/font><\/p>\n<p><font>\u5982\u4eca\uff0c\u968f\u7740\u4e00\u7bc7Nature\u8bba\u6587\u7684\u53d1\u5e03\uff0c\u53c8\u5174\u8d77\u4e86\u201c\u7b2c\u56db\u6b21\u9769\u547d\u201d\u7684\u8bf4\u6cd5\uff0c\u4e3b\u89d2\u5c45\u7136\u662f<\/font><b>\u67d3\u8272\u4f53\u5916DNA<\/b><font>(ecDNA) \u3002<\/font><\/p>\n<p><font>\u867d\u7136\u4e0a\u4e16\u7eaa60\u5e74\u4ee3\u4fbf\u6709\u4eba\u53d1\u73b0\u4e86\u8fd9\u79cd\u73af\u72b6DNA\u7684\u5b58\u5728\uff0c\u4e5f\u77e5\u9053\u5b83\u4f1a\u643a\u5e26\u764c\u57fa\u56e0\uff1b\u4f46\u4ece\u524d\u6ca1\u4eba\u76f4\u63a5\u89c2\u5bdf\u8fc7ecDNA\u3001\u6ca1\u4eba\u6307\u51fa\u5b83\u5bf9\u80bf\u7624\u7684\u751f\u957f\u6709\u591a\u5173\u952e\u3002<\/font><\/p>\n<p><font>\u800cNature\u53d1\u5e03\u7684\u65b0\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u7ec8\u4e8e<\/font><b>\u9996\u6b21\u76f4\u63a5\u89c2\u5bdf\u4e86ecDNA (\u4e0d\u6b62\u57fa\u56e0\u6d4b\u5e8f)<\/b><font>\uff0c\u5e76\u8bc1\u660e\u4e86\u5b83\u7684\u91cd\u8981\u6027\uff1a<\/font><\/p>\n<blockquote><p>ecDNA\u4e0a\u7684\u764c\u57fa\u56e0\uff0c\u662f\u80bf\u7624\u7684\u6574\u4e2a\u57fa\u56e0\u8f6c\u5f55\u7ec4\u5f53\u4e2d\uff0c\u8868\u8fbe\u6c34\u5e73\u6700\u9ad8\u7684\u90a3\u90e8\u5206\u57fa\u56e0\u3002\u800c\u67d3\u8272\u4f53\u4e0a\u764c\u57fa\u56e0\u7684\u8868\u8fbe\u76f8\u5bf9\u8f83\u4f4e\u3002<\/p><\/blockquote>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/748\/w1080h468\/20191202\/338e-ikcacer4937341.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>ecDNA\u4e0a\u7684\u764c\u57fa\u56e0\u4e4b\u6240\u4ee5\u6bd4\u67d3\u8272\u4f53\u4e0a\u7684\u764c\u57fa\u56e0\u66f4\u80fd\u53d1\u6325\u4f5c\u7528\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u4e0d\u50cf\u67d3\u8272\u4f53\u90a3\u6837\u53d7\u5230\u4e25\u683c\u4fdd\u62a4\uff0c\u5b83\u66f4\u5bb9\u6613\u8bfb\u53d6\uff0c\u80fd\u5feb\u901f\u6269\u589e\uff0c\u5177\u6709\u4fb5\u7565\u6027\u3002\u4ece\u524d\uff0c\u764c\u75c7\u79d1\u5b66\u5bb6\u4e13\u6ce8\u4e8e\u67d3\u8272\u4f53\uff0c\u800c\u65b0\u7684\u7814\u7a76\u6709\u52a9\u4e8e\u6539\u53d8\u4ed6\u4eec\u5bf9\u80bf\u7624\u7684\u8ba4\u77e5\u3002<\/font><\/p>\n<p><font>\u7814\u7a76\u6210\u679c\u6765\u81ea\u8def\u5fb7\u7ef4\u5e0c\u764c\u75c7\u7814\u7a76\u6240 (Ludwig Cancer Institute) \u548c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff0c\u8bba\u6587\u7684\u4e00\u4f5c\u662f\u4f4d\u540d\u53eb\u5434\u601d\u6db5\u7684\u534e\u4eba\u5b66\u8005\u3002<\/font><\/p>\n<p><font>\u7814\u7a76\u7ed3\u679c\u4e00\u7ecf\u516c\u5e03\uff0c\u4fbf\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5728\u77e5\u4e4e\u70ed\u699c\u4e0a\u5df2\u6709600+\u4e07\u7684\u70ed\u5ea6\u3002<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/486\/w1080h206\/20191202\/387f-ikcacer4937670.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u7f51\u53cb\u70b9\u8bc4\uff0c\u8fd9\u6b21\u53d1\u73b0\u6216\u8bb8\u5c06\u5e26\u6765\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u7b2c\u56db\u6b21\u9769\u547d\u3002<\/font><\/p>\n<p><font>\u4e00\u4f5c\u5434\u601d\u6db5\u4e5f\u7ad9\u4e86\u51fa\u6765\uff0c\u4eb2\u81ea\u5bf9\u8fd9\u4e2a\u8bdd\u9898\u4e0b\u8bfb\u8005\u7684\u79cd\u79cd\u95ee\u9898\u7b54\u7591\u89e3\u60d1\u3002<\/font><\/p>\n<p><font>\u4eca\u5929\uff0c\u91cf\u5b50\u4f4d\u5c31\u5e26\u5927\u5bb6\u9886\u7565\u4e00\u4e0b\u8fd9\u7bc7\u91cd\u8981\u7684\u7814\u7a76\u3002<\/font><\/p>\n<h2>\u66f4\u5f3a\u5927\u7684\u764c\u57fa\u56e0<\/h2>\n<p><font>\u9996\u5148\u4ecb\u7ecd\u4e00\u4e0b\uff0cecDNA\u4e0d\u662f\u539f\u672c\u5c31\u957f\u5728\u67d3\u8272\u4f53\u4e4b\u5916\uff0c\u800c\u662f\u5728\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\u4e2d\u671f\uff0c\u4ece\u67d3\u8272\u4f53\u4e0a\u8131\u843d\u4e0b\u6765\u6210\u73af\u7684DNA\u5206\u5b50\uff0c\u5e38\u5e38\u5e26\u6709\u764c\u57fa\u56e0\u3002\u8fd9\u662f\u5df2\u6709\u7684\u7814\u7a76\u6210\u679c\u3002<\/font><\/p>\n<p><font>\u4ece\u524d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5927\u591a\u662f\u4f9d\u9760\u57fa\u56e0\u6d4b\u5e8f\uff0c\u6765\u89c2\u5bdfDNA\u91cc\u7684\u764c\u57fa\u56e0\u3002<\/font><\/p>\n<p><font>\u4e00\u95e8\u5fc3\u601d\u627e\u51fa\u90a3\u4e9b\u4f1a\u4fc3\u53d1\u764c\u75c7\u7684\u57fa\u56e0\uff0c\u5374\u5ffd\u7565\u4e86\u57fa\u56e0\u7684\u7269\u7406\u4f4d\u7f6e\uff0c\u5728\u764c\u75c7\u4e2d\u7684\u610f\u4e49\u3002<\/font><\/p>\n<p><font>\u800c\u8fd9\u4e2a\u95ee\u9898\u5f88\u91cd\u8981\uff0c\u5b83\u4f1a\u5f71\u54cd\u4eba\u4eec\u5bf9\u764c\u75c7\u539f\u7406\u7684\u7406\u89e3\uff0c\u4e5f\u4f1a\u5f71\u54cd\u4eba\u4eec\u5bfb\u627e\u6cbb\u7597\u65b9\u6848\u7684\u601d\u8def\u3002<\/font><\/p>\n<p><font>\u65e2\u7136\u4e0d\u80fd\u53ea\u7528\u57fa\u56e0\u6d4b\u5e8f\uff0c\u90a3\u8fd8\u8981\u600e\u4e48\u529e\uff1f<\/font><\/p>\n<p><font>\u9996\u5148\uff0c\u56e2\u961f\u628a\u4e9a\u663e\u5fae\u7ed3\u6784\u6210\u50cf (Ultrastructrual Imaging) \u3001\u5149\u5b66\u5339\u914d (Optical Mapping) \u3001\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f (WGS) \u7b49\u7b49\u642d\u914d\u5728\u4e00\u8d77\uff0c\u6e05\u6670\u5c55\u73b0\u51fa\u4e86\u73af\u72b6DNA\u7684\u5f62\u6001\uff0c\u5c31\u662f\u9ec4\u8272\u6807\u6ce8\u90e8\u5206\uff1a<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/65\/w1080h585\/20191202\/f189-ikcacer4937960.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u867d\u7136\uff0c1960\u5e74\u4ee3\u4fbf\u6709\u79d1\u5b66\u5bb6\u53d1\u73b0\u8fc7ecDNA\u7684\u5b58\u5728\uff0c\u4e5f\u63d0\u51fa\u5b83\u662f\u73af\u72b6DNA\uff0c\u4f46\u8fd9\u7bc7\u8bba\u6587\u7ed9\u51fa\u4e86\u5b8c\u6574\u7684\u8bc1\u660e\uff0c\u524d\u4eba\u6ca1\u6709\u505a\u5230\u8fc7\u3002<\/font><\/p>\n<p><font>\u800c\u5728\u4e86\u89e3\u7ed3\u6784\u7684\u540c\u65f6\uff0c\u4e5f\u53ef\u4ee5\u53d1\u73b0ecDNA\u4e0a\u666e\u904d\u5e26\u6709\u764c\u57fa\u56e0\u3002<\/font><\/p>\n<p><font>ecDNA\u4e0a\u7684\u764c\u57fa\u56e0\u548c\u67d3\u8272\u4f53DNA\u4e0a\u7684\u764c\u57fa\u56e0\uff0c\u90fd\u4f1a\u88ab\u8f6c\u5f55\uff0c\u4ece\u800c\u63a8\u52a8\u764c\u75c7\u75c5\u60c5\u7684\u53d1\u5c55\u3002<\/font><\/p>\n<p><font>\u4f46\u7531\u4e8e\u4e24\u7c7b\u764c\u57fa\u56e0\u6240\u5728\u7684\u4f4d\u7f6e\u4e0d\u540c\uff0c\u53d1\u6325\u7684\u4f5c\u7528\u4e5f\u65e0\u6cd5\u7b49\u540c\u3002<\/font><\/p>\n<p><font>\u4e0b\u56fe\u53ef\u4ee5\u770b\u51fa\uff0c\u73af\u72b6DNA\u6bd4\u67d3\u8272\u4f53\u4e0a\u7684\u7ebf\u6027DNA\uff0c\u6269\u589e\u80fd\u529b\u8981\u5f3a\u8bb8\u591a\uff0c\u4e5f\u5c31\u66f4\u6709\u80fd\u529b\u652f\u6301\u764c\u57fa\u56e0\u7684\u8868\u8fbe\uff1a<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/34\/w1080h554\/20191202\/80d1-ikcacer4938266.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u4e5f\u5c31\u662f\u8bf4\uff0cecDNA\u80fd\u4ea7\u751f\u5927\u91cf\u7684\u526f\u672c\u3002<\/font><\/p>\n<p><font>\u7ed3\u5408\u540c\u4e00\u652f\u56e2\u961f2017\u5e74\u53d1\u8868\u7684Nature\u7814\u7a76\uff0c\u6709\u4e1d\u5206\u88c2\u5f53\u4e2d\u526f\u672c\u4e0d\u4f1a\u5e73\u5747\u5206\u5230\u4e24\u4e2a\u7ec6\u80de\u91cc\uff0c\u800c\u662f\u968f\u673a\u5206\u914d\u3002\u8fd9\u5c31\u5bfc\u81f4\u4e0d\u540c\u7ec6\u80de\u4e4b\u95f4\uff0cecDNA\u542b\u91cf\u5dee\u5f02\u5de8\u5927\uff0c\u526f\u672c\u8d8a\u591a\u5dee\u5f02\u8d8a\u5927\u3002\u80bf\u7624\u7ec6\u80de\u6709\u4e86\u5145\u8db3\u7684\u591a\u6837\u6027\uff0c\u4fbf\u80fd\u66f4\u597d\u5730\u5e94\u5bf9\u73af\u5883\u53d8\u5316\u3002<\/font><\/p>\n<p><font>\u8fd9\u91cc\u8bf4\u7684\u73af\u5883\u53d8\u5316\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u6307\u60a3\u8005\u63a5\u53d7\u4e86\u5316\u7597\/\u653e\u7597\u7b49\u7b49\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u591a\u6837\u6027\u53ef\u4ee5\u652f\u6301\u80bf\u7624\u5feb\u901f\u8fdb\u5316\uff0c\u4ea7\u751f<\/font><b>\u6297\u836f\u6027<\/b><font>\u3002\u8fd9\u4e5f\u662f\u665a\u671f\u764c\u75c7\u96be\u6cbb\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/font><\/p>\n<p><font>\u6240\u4ee5\uff0c\u764c\u57fa\u56e0\u5927\u91cf\u6269\u589e\u4e4b\u540e\uff0c\u5c31\u80fd\u5927\u91cf\u8868\u8fbe\u4e48\uff1f<\/font><\/p>\n<p><font>\u5728\u521a\u521a\u53d1\u8868\u7684\u8bba\u6587\u91cc\uff0c\u56e2\u961f\u4e5f\u7528\u5b9e\u9a8c\u8bc1\u660e\uff0c\u764c\u7ec6\u80de\u91cc\u8868\u8fbe\u6c34\u5e73\u66f4\u9ad8\u7684\u90a3\u4e9b\u764c\u57fa\u56e0\uff0c\u5c31\u662f\u6765\u81eaecDNA\u8eab\u4e0a\u7684\u764c\u57fa\u56e0\uff1a<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/249\/w1080h769\/20191202\/a211-ikcacer4938543.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u8fd9\u662f\u6d4b\u5e8f\u7ed3\u679c\uff0c\u4e0a\u9762\u662f\u764c\u57fa\u56e0\u8f6c\u5f55\u7684mRNA\u5e8f\u5217\uff0c\u4e0b\u9762\u662f\u764c\u57fa\u56e0\u672c\u8eab\u7684DNA\u5e8f\u5217\u3002\u5de6\u8fb9\u9ec4\u8272\u90e8\u5206\uff0c\u662f\u9ad8\u6269\u589e\u9ad8\u8f6c\u5f55\u7684ecDNA\uff0c\u53f3\u8fb9\u662f\u4f4e\u6269\u589e\u4f4e\u8f6c\u5f55\u7684\u67d3\u8272\u4f53DNA\u3002<\/font><\/p>\n<p><font>\u5982\u6b64\u4e00\u6765\uff0c\u9ad8\u6269\u589e\u4e0e\u9ad8\u8f6c\u5f55 (\u9ad8\u8868\u8fbe) \u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5f97\u5230\u4e86\u8bc1\u660e\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u6bd4\u8d77\u67d3\u8272\u4f53\u4e0a\u7684\u764c\u57fa\u56e0\uff0cecDNA\u4e0a\u7684\u764c\u57fa\u56e0\u6709\u66f4\u5f3a\u7684\u529b\u91cf\uff0c\u63a8\u52a8\u764c\u75c7\u75c5\u60c5\u5411\u524d\u53d1\u5c55\u3002<\/font><\/p>\n<p><font>\u90a3\u4e48\u95ee\u9898\u6765\u4e86\uff0cecDNA\u6bd5\u7adf\u662f\u4ece\u67d3\u8272\u4f53\u4e0a\u8131\u843d\u7684\uff0c\u4e3a\u4ec0\u4e48\u67d3\u8272\u4f53\u4e0a\u7684\u764c\u57fa\u56e0\uff0c\u5c31\u6ca1\u6709\u90a3\u4e48\u5927\u7684\u5a01\u529b\u5462\uff1f<\/font><\/p>\n<p><font>\u56e2\u961f\u8bf4\uff0c\u8fd9\u662f\u56e0\u4e3aecDNA\u7684\u5f00\u653e\u6027\u6bd4\u67d3\u8272\u4f53\u8981\u5f3a\u5f88\u591a\u3002<\/font><\/p>\n<p><font>\u4e00\u662f\u6d4b\u5e8f\u5b9e\u9a8c\u8bc1\u660e\u4e86\uff0cecDNA\u8868\u9762\u7f3a\u5c11\u6291\u5236\u8f6c\u5f55\u7684\u7ec4\u86cb\u767d\u4fee\u9970 (Repressive Histone Mark) \uff0c\u540c\u65f6\u53c8\u6709\u6d3b\u8dc3\u578b\u7684\u7ec4\u86cb\u767d\u4fee\u9970\uff1b\u800c\u4e14\uff0c\u8fd9\u4e9b\u7ec4\u86cb\u767d\u53c8\u5728\u542f\u52a8\u5b50 (\u8f6c\u5f55\u5f00\u59cb) \u7684\u4f4d\u7f6e\u4e0a\u3002<\/font><\/p>\n<p><font>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u67d3\u8272\u4f53DNA\u4e0a\u7684\u57fa\u56e0\uff0c\u901a\u5e38\u662f\u88ab\u6291\u5236\u8f6c\u5f55\u7684\u3002<\/font><\/p>\n<p><font>\u4e8c\u662fecDNA\u4f5c\u4e3a\u4e00\u79cd\u73af\u72b6DNA\uff0c\u6ca1\u6709\u67d3\u8272\u4f53\u7684\u90a3\u79cd\u9ad8\u7ea7\u538b\u7f29\u7ed3\u6784 (Higher-Order Compaction) \uff0c\u8fd9\u4e5f\u4f1a\u8ba9\u57fa\u56e0\u8f6c\u5f55\u53d8\u5f97\u66f4\u5bb9\u6613\uff1a<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/173\/w1080h693\/20191202\/d5a9-ikcacer4938989.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u81f3\u4e8eecDNA\u7684\u5927\u89c4\u6a21\u590d\u5236\uff0c\u5230\u5e95\u662f\u600e\u6837\u8fbe\u6210\u7684\uff0c\u56e2\u961f\u4e5f\u8fd8\u5728\u7814\u7a76\u4e2d\u3002<\/font><\/p>\n<p><font>\u4e0d\u8fc7\uff0c\u76ee\u524d\u7684\u7814\u7a76\u6210\u679c\uff0c\u5e26\u6765\u7684\u6700\u91cd\u8981\u7684\u542f\u53d1\u5927\u6982\u5c31\u662f\uff1a<\/font><\/p>\n<p><b>\u4e0d\u8981\u53ea\u76ef\u7740\u67d3\u8272\u4f53\u4e0a\u7684\u764c\u57fa\u56e0\uff0c\u73af\u72b6\u7684ecDNA\u4e5f\u53ef\u80fd\u5e26\u6211\u4eec\u627e\u5230\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002<\/b><\/p>\n<h2>\u4e00\u4f5c\u5434\u601d\u6db5\u73b0\u8eab\u7b54\u7591\u89e3\u60d1<\/h2>\n<p><font>\u6309\u7167\u300c\u8c22\u9080\uff0c\u4eba\u5728\u77e5\u4e4e\uff0c\u521a\u53d1\u300aNature\u300b\u300d\u7684\u60ef\u4f8b\uff0c\u8bba\u6587\u4e00\u4f5c\u5434\u601d\u6db5\u5982\u7ea6\u73b0\u8eab\u77e5\u4e4e\uff0c\u5bf9\u8bba\u6587\u8fdb\u884c\u4e86\u7b54\u7591\u89e3\u60d1\u3002<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/609\/w1080h1129\/20191202\/b013-ikcacer4939279.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u91cf\u5b50\u4f4d\u7ecf\u6388\u6743\uff0c\u5bf9\u95ee\u9898\u548c\u4f5c\u8005\u7684\u89e3\u7b54\u505a\u4e86\u6574\u7406\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u4e00<\/b><font>\uff1a\u764c\u75c7\u7684\u4e09\u5927\u7279\u6027\uff1a\u4fb5\u88ad\u6027\uff0c\u5373\u764c\u75c7\u53ef\u4ee5\u628a\u5468\u56f4\u7684\u6b63\u5e38\u7ec6\u80de\u53d8\u6210\u764c\u7ec6\u80de\u3002<\/font><\/p>\n<p><font>\u8fd9\u79cd\u7b56\u7565\uff0c\u662f\u4e0d\u662f\u901a\u8fc7\u8fd9\u79cdecDNA\u5b9e\u73b0\u7684\u5462\uff1f\u6bd5\u7adf\u5728\u5e7f\u5927\u751f\u7269\u4e2d\uff0c\u901a\u8fc7\u8d28\u7c92\u4f20\u9012\u8fd9\u79cd\u57fa\u56e0\u6c34\u5e73\u8f6c\u79fb\u662f\u5e7f\u6cdb\u5b58\u5728\u7684\u2014\u2014CNS\u7ea7\u522b<\/font><\/p>\n<p><b>\u7b54<\/b><font>\uff1a\u9996\u5148\uff0c\u6211\u4eec\u5728\u4e0b\u4e00\u7bc7\u6587\u7ae0\u4e2d\uff0c\u5c31\u6709\u5728\u5173\u6ce8ecDNA\u548c\u80bf\u7624\u8f6c\u79fb\u7684\u5173\u7cfb\uff08\u4fb5\u88ad\u6682\u65e0\u6570\u636e\uff09\u3002\u4f46\u662f\uff0c\u8fd9\u662f\u672a\u53d1\u8868\u6570\u636e\uff0c\u6240\u4ee5\u4e0d\u4fbf\u900f\u9732\u3002\u800c\u4e14\u6211\u4e2a\u4eba\u8fd8\u5728\u8d28\u7591\u76ee\u524d\u6570\u636e\u7684\u53ef\u9760\u7a0b\u5ea6\uff0c\u56e0\u4e3a\u6211\u8ba4\u4e3a\u8fd8\u9700\u8981\u8fdb\u884c\u66f4\u591a\u7ec6\u81f4\u7684\u4e9a\u7ec4\u5206\u6790\uff0c\u624d\u80fd\u7ed9\u51fa\u7b54\u6848\u3002<\/font><\/p>\n<p><font>\u81f3\u4e8eecDNA\u80fd\u5426\u5b9e\u73b0\u7c7b\u4f3c\u8d28\u7c92\u4e00\u822c\u7684\u6a2a\u7ebf\u8f6c\u79fb\uff0c\u6211\u4eec\u7684\u731c\u6d4b\uff0c\u662f\u6709\u53ef\u80fd\u3002\u4f46\u662f\uff0c\u51e0\u7387\u591a\u5927\uff1f\u6709\u6ca1\u6709\u751f\u7269\u5b66\u610f\u4e49\uff1f\u8fd9\u662f\u76ee\u524d\u4e0d\u6e05\u695a\u7684\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u4e8c<\/b><font>\uff1aecDNA\u600e\u4e48\u4ece\u67d3\u8272\u4f53\u4e0a\u6389\u4e0b\u6765\uff1f<\/font><\/p>\n<p><font>\u6240\u6709\u73b0\u6709\u7684\u8bc1\u636e\u90fd\u6307\u5411\uff0cecDNA\u7684\u5f62\u6210\uff0c\u6781\u5927\u51e0\u7387\u548cDNA\u635f\u4f24\uff08\u5c24\u5176\u662fDNA\u53cc\u94fe\u65ad\u94fe\uff09\u6709\u5173\u3002<\/font><\/p>\n<p><font>\u5176\u4e2d\uff0c\u4ee5\u524d\u8ddf\u6211\u4eec\u540c\u4e00\u4e2a\u5b9e\u9a8c\u697c\u7684\u524d\u8f88\u6709\u6587\u7ae0\u8868\u660e\uff0clagging chromosome\u5bf9\u5bfc\u81f4\u67d3\u8272\u4f53\u788e\u88c2\uff0c\u5e76\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4f1a\u5728\u5b50\u4ee3\u7ec6\u80de\u4e2d\u5f62\u6210ecDNA\u3002<\/font><\/p>\n<p><font>\u4f46\u7531\u4e8e\u4ed6\u4eec\u7528\u7684\u662f\u4e00\u4e2a\u4eba\u9020\u7684lagging Y\u67d3\u8272\u4f53\u6a21\u578b\uff0c\u6240\u4ee5\u8ddf\u80bf\u7624\u4e2d\u7684\u60c5\u51b5\u8fd8\u662f\u4e0d\u4e00\u6837\u3002\u4e0d\u8fc7\uff0c\u8fd9\u5176\u4e2d\u5e94\u8be5\u6709\u76f8\u901a\u4e4b\u5904\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u4e09<\/b><font>\uff1aecDNA\u600e\u4e48\u6d88\u9664\uff1f<\/font><\/p>\n<p><b>\u7b54<\/b><font>\uff1a\u6211\u4eec\u57282014\u5e74\uff0c\u6709\u4e00\u7bc7Science\u6587\u7ae0\u7814\u7a76\u4e86\u8fd9\u4e2a\u95ee\u9898\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u5f53ecDNA\u4e0a\u9762\u542b\u6709EGFR\u57fa\u56e0\u7684\u65f6\u5019\uff0c\u7528EGFR\u7684\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u201c\u6d88\u9664\u201decDNA\u3002<\/font><\/p>\n<p><font>\u4f46\u662f\uff0c\u8fd9\u4e9becDNA\u4f1a\u201c\u85cf\u201d\u5230\u67d3\u8272\u4f53\u4e0a\u3002\u4e00\u65e6\u64a4\u836f\uff0c\u8fd9\u4e9becDNA\u5c31\u4f1a\u6b7b\u7070\u590d\u71c3\uff0c\u91cd\u65b0\u51fa\u73b0\u3002<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/797\/w1080h517\/20191202\/0ad9-ikcacer4939599.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/science.sciencemag.org\/content\/343\/6166\/72<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/663\/w1080h383\/20191202\/c2bb-ikcacer4940036.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u4e0a\u56fe\u5206\u522b\u662f\u201c\u62ff\u8863\u670d\u201d\uff0c\u201c\u836f\u7269\u62b5\u6297\u201d\uff0c\u548c\u201c\u64a4\u836f\u201d\u72b6\u6001\u3002<\/font><\/p>\n<p><font>\u5176\u4ed6\u7ec4\u4e5f\u6709\u5728\u505a\u6709\u5173ecDNA\u7684\u6d88\u9664\u673a\u5236\uff0c\u5305\u62ec\u6709\u7528\u4e00\u4e9b\u6297\u764c\u836f\u7f9f\u57fa\u8132\u6765\u5b9e\u73b0\u7684\u3002<\/font><\/p>\n<p><font>\u6211\u4eec\u5b9e\u9a8c\u5ba4\u73b0\u5728\u5df2\u7ecf\u53d1\u73b0\u4e86ecDNA\u6d88\u9664\u7684\u7edf\u4e00\u673a\u5236\uff0c\u4f46\u7531\u4e8e\u662f\u672a\u53d1\u8868\u6570\u636e\uff0c\u6240\u4ee5\uff0c\u65e0\u53ef\u5949\u544a\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u56db<\/b><font>\uff1a\u4e0d\u53ea\u6709\u764c\u57fa\u56e0\u5427\uff0c\u4f1a\u4e0d\u4f1a\u6709\u6291\u764c\u57fa\u56e0\u5728\u4e0a\u9762\u5462\uff1f<\/font><\/p>\n<p><b>\u7b54<\/b><font>\uff1a\u76ee\u524d\u6211\u4eec\u53ea\u53d1\u73b0\u4e86\u4e0a\u9762\u5e26\u6709oncogene\uff0c\u4f46\u6ca1\u6709\u53d1\u73b0\u3010\u7ecf\u5178\u7684\u3011tumor suppressor gene\u3002\uff08\u4e3a\u4ec0\u4e48\u8981\u8bf4\u662f\u3010\u7ecf\u5178\u3011\u5462\uff0c\u56e0\u4e3a\u9b3c\u77e5\u9053\u4f1a\u4e0d\u4f1a\u54ea\u5929\u53d1\u73b0\u4e86\u54ea\u4e2a\u65b0\u7684\u6291\u764c\u57fa\u56e0\u5462\u3002\u800c\u4e14\u6211\u5c06\u6709\u4e00\u7bc7\u5408\u4f5c\u6587\u7ae0\uff0c\u5c31\u627e\u5230\u4e86\u4e00\u4e2a\u975e\u7ecf\u5178\u6291\u764c\u57fa\u56e0\uff0c\u9003~\uff09<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/256\/w630h1226\/20191202\/e63f-ikcacer4940313.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u8fd9\u662f\u6211\u4eec\u7ec42017\u5728Nature\u4e0a\u53d1\u7684\u6587\u7ae0\u7684\u6570\u636e\uff1a<\/font><\/p>\n<p><font>Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity<\/font><\/p>\n<p><font>\u7ea2\u8272\u7684\u662fTCGA\u6570\u636e\u5e93\u4e0a\u6269\u589e\u7684\u539f\u764c\u57fa\u56e0\u5206\u5e03\uff0c\u53f3\u8fb9\u662f\u6211\u4eec\u7684\u6837\u672c\u3002\u53ef\u4ee5\u770b\u51fa\uff0c\u4e24\u8005\u5728\u6269\u589e\u7684\u539f\u764c\u57fa\u56e0\u7684\u7c7b\u522b\u4e0a\uff0c\u662f\u6709\u76f8\u5f53\u5927\u7684\u91cd\u5408\u7684\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u4e94<\/b><font>\uff1aecDNA\u662f\u5426\u6709\u7edf\u4e00\u5f62\u6210\u673a\u5236\uff1f\u5b83\u4eec\u7684\u8f6c\u5f55\u548c\u590d\u5236\u662f\u5426\u548c\u67d3\u8272\u4f53DNA\u4e00\u6837\uff1f<\/font><\/p>\n<p><font>\u5e76\u4e0d\u6e05\u695a\u662f\u5426\u6709\u7edf\u4e00\u673a\u5236\u3002\u6211\u4eec\u4ec5\u4ec5\u77e5\u9053\uff0c\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u53ef\u4ee5\u4eba\u5de5\u5728\u6b63\u5e38\u548c\u80bf\u7624\u7ec6\u80de\u4e2d\u521b\u9020\u51faecDNA\u3002\u4f46\u8ddd\u79bb\u8fd9\u4e2aecDNA\u662f\u5426\u6709\u529f\u80fd\uff0c\u8fd8\u6709\u5f88\u957f\u7684\u8ddd\u79bb\u8981\u8d70\u3002<\/font><\/p>\n<p><font>ecDNA\u7684\u8f6c\u5f55\u548c\u590d\u5236\u673a\u5236\uff0c\u662f\u4e0d\u6e05\u695a\u7684\u3002\u8fd9\u5c31\u662f\u8fd9\u4e2a\u9886\u57df\u6709\u610f\u601d\u7684\u5730\u65b9\uff0c\u6709\u7740\u5927\u91cf\u7684\u672a\u77e5\u7b49\u7740\u6211\u4eec\u53bb\u63a2\u7d22\u3002<\/font><\/p>\n<p><b>\u95ee\u9898\u516d<\/b><font>\uff1aecDNA\u7684\u590d\u5236\u662f\u600e\u6837\u7684\uff1f\u7c7b\u4f3c\u4e8e\u8d28\u7c92\u7684\u81ea\u6211\u590d\u5236\u8fd8\u662f\u6709\u5176\u4ed6\u65b9\u5f0f\uff1f<\/font><\/p>\n<p><b>\u7b54<\/b><font>\uff1a\u8d28\u7c92\u590d\u5236\u53ef\u80fd\u81f3\u5c11\u67093\u79cd\u65b9\u5f0f\uff0c\u6bd4\u5982\u03b8\u673a\u5236\uff0c\u6eda\u73af\u590d\u5236\u7b49\u3002\u4f46\u81f3\u4e8eecDNA\u7684\u590d\u5236\u65b9\u5f0f\uff0c\u8ddf\u4ec0\u4e48\u6bd4\u8f83\u50cf\uff1f\u6211\u4eec\u73b0\u6709\u7684\u6570\u636e\u548c\u5047\u8bf4\uff0c\u6709\u70b9\u82d7\u5934\u3002\u4f46\u662f\uff0c\u5177\u4f53\u600e\u4e48\u6837\uff0c\u6211\u4eec\u4e5f\u4e0d\u6e05\u695a\u3002\u8fd9\u4e5f\u662f\u6211\u4eec\u672a\u6765\u5c06\u8981\u7814\u7a76\u7684\u95ee\u9898\u3002<\/font><\/p>\n<h2>\u522b\u4eba\u600e\u4e48\u770b\uff1f<\/h2>\n<p><font>\u90a3\u4e48\uff0c\u8fd9\u6837\u4e00\u4e2a\u53d1\u73b0\u4e3a\u4ec0\u4e48\u53ef\u80fd\u5e26\u6765<\/font><b>\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u7b2c\u56db\u6b21\u9769\u547d<\/b><font>\u5462\uff1f<\/font><\/p>\n<p><font>\u4e2d\u56fd\u79d1\u5b66\u9662\u9057\u4f20\u5b66\u535a\u58eb\u674e\u96f7\u5728\u77e5\u4e4e\u56de\u7b54\u4e86\u8fd9\u4e2a\u95ee\u9898\uff0c\u5e76\u83b7\u5f97\u4e86\u8fd15.2K\u7684\u70b9\u8d5e\u3002<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/514\/w1080h234\/20191202\/4bed-ikcacer4940874.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<blockquote><p>\u56e0\u4e3a\uff0c\u6211\u4eec\u627e\u5230\u4e86\u764c\u57fa\u56e0\u771f\u6b63\u5728\u54ea\u91cc\uff01<\/p><\/blockquote>\n<blockquote><p>\u5728\u4eca\u5929\uff0c\u76f8\u4fe1\u8def\u8fb9\u6446\u644a\u7684\u5927\u7237\u90fd\u77e5\u9053\u764c\u57fa\u56e0\u8fd9\u79cd\u6982\u5ff5\uff0c\u662f\u7684\uff0c\u8fc7\u53bb\u51e0\u5341\u5e74\uff0c\u501f\u52a9\u6d4b\u5e8f\u6280\u672f\uff0c\u79d1\u5b66\u5bb6\u4eec\u7814\u7a76\u4e86\u5927\u91cf\u7684\u548c\u764c\u75c7\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u6bd4\u5982nature\u66fe\u7ecf\u53d1\u4e0d\u8fc7\u5168\u7403\u6700\u706b\u768410\u4e2a\u57fa\u56e0\uff0c\u7b2c\u4e00\u4e2a\u5c31\u662f\u6291\u764c\u57fa\u56e0tp53\uff0c\u5176\u4ed6\u7684\u4e5f\u5927\u90e8\u5206\u90fd\u662f\u764c\u57fa\u56e0\uff0c\u4f46\u662f\uff0c\u764c\u57fa\u56e0\u7684\u7269\u7406\u4f4d\u7f6e\u5230\u5e95\u5728\u54ea\u91cc\uff1f\u6211\u4eec\u5374\u4e00\u76f4\u641e\u9519\u4e86\u3002<\/p><\/blockquote>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/743\/w491h252\/20191202\/ec47-ikcacer4941208.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<blockquote><p>\u8fc7\u53bb\u6211\u4eec\u4e00\u76f4\u4ee5\u4e3a\u764c\u57fa\u56e0\u5728\u67d3\u8272\u4f53\u4e0a\uff0c\u6bd5\u7adf\u6b63\u5e38\u4eba\u7684\u57fa\u56e0\u90fd\u662f\u5728\u67d3\u8272\u4f53\u4e0a\uff0c\u7136\u800c\uff0c\u5434\u601d\u6db5\u4ed6\u4eec\u7684\u7814\u7a76\u5374\u53d1\u73b0\uff0c\u5728\u764c\u75c7\u4e2d\uff0c\u8fd9\u4e00\u60c5\u51b5\u53d1\u751f\u4e86\u6539\u53d8\uff0c\u764c\u7ec6\u80de\u4e2d\u7684\u764c\u57fa\u56e0\u7adf\u7136\u4ece\u67d3\u8272\u4f53\u4e0a\u6389\u4e0b\u6765\uff0c\u5f62\u6210\u4e86\u4e00\u79cd\u7279\u6b8a\u7684DNA\uff0c\u90a3\u5c31\u662f\u73af\u72b6ecDNA\u3002<\/p><\/blockquote>\n<p><font>\u5317\u4eac\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u535a\u58eb\u5b5f\u6d69\u5dcd\u8bc4\u4ef7\u9053\uff1a<\/font><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/499\/w1080h219\/20191202\/0d3c-ikcacer4941411.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u7279\u522b\u4f69\u670d\u8fd9\u79cd\u539f\u521b\u6027\u7684\u7814\u7a76\uff0c\u8fd9\u79cd\u7814\u7a76\u624d\u771f\u7684\u662f\u5f00\u521b\u4e00\u4e2a\u65b0\u9886\u57df\uff0c\u80fd\u8fc7\u4e3a\u4f17\u591a\u7814\u7a76\u4eba\u5458\u6253\u5f00\u4e00\u4e2a\u65b0\u9886\u57df\u7684\u5927\u95e8\uff1b\u800c\u4e0d\u662f\u67d0\u4e9b\u4eba\uff0c\u9760\u5806\u4eba\u529b\u7269\u529b\u641e\u519b\u5907\u7ade\u8d5b\uff0c\u5728\u6709\u9650\u7684\u9886\u57df\u3001\u6709\u9650\u95ee\u9898\u91cc\u4e92\u76f8\u62a2\u996d\u7897\u3002<\/font><\/p>\n<h2>\u4f5c\u8005\u7b80\u4ecb<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/n.sinaimg.cn\/sinacn20113\/728\/w678h850\/20191202\/0ed7-ikcacer4941705.jpg\" alt=\"Nature\uff1a\u6700\u5f3a\u764c\u57fa\u56e0\u627e\u5230\u4e86\uff0c\u5c45\u7136\u4e0d\u5728\u67d3\u8272\u4f53\u4e0a | \u534e\u4eba\u9886\u8854\u6700\u65b0\u7814\u7a76\"><\/p>\n<p><font>\u5434\u601d\u6db5\u5728\u4e2d\u5c71\u5927\u5b66\u653b\u8bfb\u5b8c\u535a\u58eb\u5b66\u4f4d\u540e\uff0c\u4e8e2014\u5e74\u52a0\u5165Paul Mischel Lab\u3002<\/font><\/p>\n<p><font>\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u662f\u764c\u75c7\u9057\u4f20\u5b66\u548c\u4ee3\u8c22\uff0c\u63a2\u7a76\u67d3\u8272\u4f53\u5916DNA\u5982\u4f55\u4f7f\u764c\u75c7\u9002\u5e94\uff0c\u4ee5\u53ca\u91cd\u65b0\u7f16\u7a0b\u7684\u7ec6\u80de\u4ee3\u8c22\u5982\u4f55\u652f\u6301\u764c\u75c7\u751f\u5b58\u3002<\/font><\/p>\n<p><font>(<\/font>\u91cf\u5b50\u4f4d)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a \u764c\u75c7\u96be\u6cbb\uff0c\u7f6a\u9b41\u7978\u9996\u7adf\u7136\u662f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14],"tags":[],"class_list":["post-13839","post","type-post","status-publish","format-standard","hentry","category-health"],"_links":{"self":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13839"}],"version-history":[{"count":0,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13839\/revisions"}],"wp:attachment":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13839"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}