{"id":13925,"date":"2020-06-02T00:00:00","date_gmt":"2020-06-01T16:00:00","guid":{"rendered":"http:\/\/15.134.89.131\/archive\/2020\/06\/02\/%e6%af%94%e9%bb%84%e9%87%91%e8%a6%81%e8%b4%b5200%e5%80%8d%ef%bc%8c%e8%bf%99%e6%ac%be%e6%8a%97%e7%99%8c%e8%8d%af%e4%b8%80%e5%b9%b4%e5%8d%96%e5%87%ba500%e4%ba%bf%e7%bb%84%e5%9b%be\/"},"modified":"2020-06-02T00:00:00","modified_gmt":"2020-06-01T16:00:00","slug":"%e6%af%94%e9%bb%84%e9%87%91%e8%a6%81%e8%b4%b5200%e5%80%8d%ef%bc%8c%e8%bf%99%e6%ac%be%e6%8a%97%e7%99%8c%e8%8d%af%e4%b8%80%e5%b9%b4%e5%8d%96%e5%87%ba500%e4%ba%bf%e7%bb%84%e5%9b%be","status":"publish","type":"post","link":"http:\/\/15.134.89.131\/archive\/?p=13925","title":{"rendered":"\u6bd4\u9ec4\u91d1\u8981\u8d35200\u500d\uff0c\u8fd9\u6b3e\u6297\u764c\u836f\u4e00\u5e74\u5356\u51fa500\u4ebf(\u7ec4\u56fe)"},"content":{"rendered":"

\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a<\/strong><\/p>\n

\n\u6587\/ \u97e9\u7490 \u7f16\u8f91\/ \u9648\u6653\u5e73<\/p>\n

\u4eca\u5e746\u6708\uff0c\u201cO\u836f\u201d\u5728\u4e2d\u56fd\u5373\u5c06\u4e0a\u5e02\u6ee12\u5e74\u3002<\/p>\n

\u8fd9\u6b3e\u6cbb\u764c\u836f\u7684\u672c\u540d\u4e3a\u6b27\u72c4\u6c83\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u201cO\u836f\u201d\u662f\u6c11\u95f4\u7684\u79f0\u547c\uff0c\u4e24\u5e74\u524d\uff0c\u4ec5\u5386\u65f67\u4e2a\u6708\uff0c\u5c31\u5b8c\u6210\u4e0a\u5e02\u7533\u8bf7\uff0c\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u836f\u7269\uff0c\u56fd\u5185\u83b7\u6279\u7684\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u80ba\u764c\u2014\u2014\u4e2d\u56fd\u7b2c\u4e00\u5927\u9ad8\u53d1\u764c\u75c7\uff0c\u53bb\u5e749\u6708\uff0c\u83b7\u6279\u7b2c\u4e8c\u4e2a\u9002\u5e94\u75c7\u5934\u9888\u90e8\u9cde\u764c\u3002<\/p>\n

\u4eca\u5e743\u6708\uff0c\u201cO\u836f\u201d\u5728\u534e\u53c8\u83b7\u51c6\u7528\u4e8e\u665a\u671f\u80c3\u764c\u60a3\u8005\uff0c\u201c\u5f97\u76ca\u4e8e\u4e2d\u56fd\u653f\u5e9c\u52a0\u5feb\u521b\u65b0\u836f\u7269\u5ba1\u8bc4\u5ba1\u6279\uff0c\u2018O\u836f\u2019\u5728\u4e2d\u56fd\u6bcf\u5e74\u90fd\u65a9\u83b7\u4e00\u4e2a\u65b0\u7684\u9002\u5e94\u75c7\u3002\u201d\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u4e2d\u56fd\u5927\u9646\u53ca\u9999\u6e2f\u5730\u533a\u603b\u7ecf\u7406\u9648\u601d\u6e0a\u544a\u8bc9\u300a21CBR\u300b\u3002<\/p>\n

\u636e\u5979\u4ecb\u7ecd\uff0c\u5728\u665a\u671f\u80c3\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u6570\u636e\u4e0a\uff0c\u201cO\u836f\u201d\u6cbb\u7597\u7ec4\u53ef\u964d\u4f4e\u6b7b\u4ea1\u98ce\u966938%\uff0c\u5bf9\u4e8e\u6cbb\u7597\u7ec4\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u6765\u8bf4\uff0c61.3%\u7684\u60a3\u8005\u751f\u5b58\u671f\u5ef6\u957f\u52302\u5e74\u4ee5\u4e0a\u3002<\/p>\n

\u4e0a\u5e026\u5e74\u591a\uff0c\u201cO\u836f\u201d\u5171\u60e0\u53ca\u8d85\u8fc730\u4e07\u540d\u60a3\u8005\uff0c\u5168\u7403\u5e74\u9500\u552e\u9ad8\u8fbe500\u4ebf\u5143\uff0c\u7531\u4e8e\u5df2\u9002\u7528\u6700\u9ad8\u53d1\u7684\u4e24\u5927\u764c\u79cd\uff0c\u5b83\u5728\u4e2d\u56fd\u65e5\u76ca\u6210\u4e00\u6b3e\u660e\u661f\u4ea7\u54c1\u3002\u8fd9\u662f\u798f\u97f3\uff0c\u4e5f\u662f\u4e00\u79cd\u4e0d\u5e78\u3002<\/p>\n

\u8bfa\u5956\u52a0\u6301\uff0c\u5e74\u9500500\u4ebf
\n<\/b>
\n\u201cO\u836f\u201d\u662f\u5168\u7403\u6700\u65e9\u83b7\u6279\u7684PD-1\u836f\u7269\uff0c\u582a\u79f0\u73b0\u4ee3\u533b\u5b66\u53f2\u4e0a\u8986\u76d6\u6700\u5e7f\u6cdb\u7684\u764c\u75c7\u6cbb\u7597\u836f\u7269\u4e4b\u4e00\u3002\u65e5\u672c\u79d1\u5b66\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\u5c45\u529f\u81f3\u4f1f\uff0c\u51fa\u751f\u4e8e\u798f\u5dde\u7684\u7f8e\u7c4d\u79d1\u5b66\u5bb6\u9648\u5217\u5e73\uff0c\u4e5f\u505a\u51fa\u4e86\u91cd\u8981\u8d21\u732e\u3002<\/p>\n

1992\u5e74\uff0c\u4eac\u90fd\u5927\u5b66\u6559\u6388\u672c\u5eb6\u4f51\u53ca\u5176\u56e2\u961f\uff0c\u5728\u5c0f\u767d\u9f20\u8eab\u4e0a\u53d1\u73b0\u4e00\u79cd\u65b0\u57fa\u56e0\uff0c\u4e00\u65e6\u5176\u88ab\u6fc0\u6d3b\uff0c\u514d\u75ab\u7cfb\u7edf\u7684T\u7ec6\u80de\u5c31\u4f1a\u88ab\u6291\u5236\uff0c\u4ed6\u5c06\u65b0\u57fa\u56e0\u547d\u540d\u4e3aPD-1\uff08Programmed cell death protein -1\uff0c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1\uff09\u3002<\/p>\n

1994\u5e74\uff0c\u672c\u5eb6\u4f51\u5728\u4eba\u4f53\u5185\u53d1\u73b0\u4e86PD-1\uff0c\u53ea\u662f\u6ca1\u6709\u4e0e\u764c\u75c7\u6302\u94a9\u30022000-2002\u5e74\u671f\u95f4\uff0c\u9648\u5217\u5e73\u7b49\u79d1\u5b66\u5bb6\u52a0\u5165\u7814\u7a76\uff0c\u8bc1\u5b9e\u4e86PD-1\u4e0e\u80bf\u7624\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

\u7b80\u5355\u8bf4\uff0c\u6b63\u5e38\u4eba\u4f53\u6bcf\u5929\u90fd\u4f1a\u4ea7\u751f\u764c\u7ec6\u80de\uff0c\u4eba\u7c7b\u81ea\u8eab\u514d\u75ab\u672c\u53ef\u4ee5\u5c06\u5176\u6740\u706d\uff0c\u4e00\u65e6PD-1\u4fe1\u53f7\u6fc0\u6d3b\uff0c\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u4f5c\u7528\u5c31\u4f1a\u53d7\u963b\u3002<\/p>\n

\u90a3\u4e48\uff0c\u53ea\u8981\u963b\u65adPD-1\u4fe1\u53f7\uff0c\u6062\u590d\u4eba\u7c7b\u4f53\u5185\u7684T\u7ec6\u80de\uff0c\u542f\u52a8\u514d\u75ab\u53cd\u5e94\uff0c\u5c31\u6709\u5e0c\u671b\u6297\u51fb\u80bf\u7624\u3002<\/p>\n

PD-1\u7684\u53d1\u73b0\u53ca\u4fe1\u606f\u901a\u8def\u7684\u660e\u786e\uff0c\u91cd\u542f\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u60f3\u6cd5\u300219\u4e16\u7eaa90\u5e74\u4ee3\uff0c\u5c31\u6709\u533b\u751f\u5c1d\u8bd5\u5728\u60a3\u8005\u4f53\u5185\u6ce8\u5c04\u94fe\u7403\u83cc\u6cbb\u7597\u80bf\u7624\uff0c\u65e0\u5948\uff0c\u5f53\u65f6\u514d\u75ab\u7597\u6cd5\u8fc7\u4e8e\u7c97\u653e\uff0c\u540e\u4e3a\u624b\u672f\u3001\u653e\u7597\u4ee5\u53ca\u5316\u7597\u7b49\u65b9\u6cd5\u6240\u6dd8\u6c70\u3002<\/p>\n

\u4f5c\u4e3a\u65b0\u7814\u7a76\u6210\u679c\uff0c\u57fa\u4e8ePD-1\u7684\u7814\u53d1\u5e76\u65e0\u6210\u529f\u5148\u4f8b\uff0c\u4e5f\u51e0\u7ecf\u574e\u5777\u3002<\/p>\n

2001\u5e74\uff0c\u672c\u5eb6\u4f51\u4e0e\u65e5\u672c\u5c0f\u91ce\u5236\u836f\u5408\u4f5c\u7533\u8bf7\u4e13\u5229\uff0c\u56e0\u4e34\u5e8a\u5f00\u53d1\u8d39\u7528\u8fc7\u4e8e\u6602\u8d35\uff0c\u76f4\u52302005\u5e74\uff0cMedarex\u516c\u53f8\u52a0\u5165\uff0c\u624d\u8fbe\u6210\u5173\u4e8ePD-1\u6297\u4f53\u7684\u5408\u4f5c\u7814\u53d1\u534f\u8bae\u3002<\/p>\n

\u8be5\u534f\u8bae\u4e2d\uff0cMedarex\u83b7\u5f97PD-1\u6291\u5236\u5242\u5728\u5317\u7f8e\u7684\u5546\u4e1a\u6743\u76ca\uff0c\u5c0f\u91ce\u5236\u836f\u5219\u83b7\u5f97\u5317\u7f8e\u4ee5\u5916\u7684\u5730\u533a\u3002<\/p>\n

PD-1\u6291\u5236\u5242\u53d6\u5f97\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5e76\u4e0d\u7a33\u5b9a\uff0c\u6bd4\u8d77\u4f20\u7edf\u836f\u7269\uff0c\u5ba2\u89c2\u5e94\u7b54\u7387\uff08\u7624\u4f53\u7f29\u5c0f\u7387\uff09\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7b49\u6570\u636e\uff0c\u6539\u5584\u4e5f\u4e0d\u660e\u663e\u3002\u5916\u754c\u4e00\u5ea6\u731c\u6d4b\uff0c\u672c\u5eb6\u4f51\u7b49\u4eba\u5df2\u4e0d\u770b\u597dPD-1\u6297\u4f53\u7684\u4ef7\u503c\u3002<\/p>\n

2009\u5e74\uff0cBMS\u4ee524\u4ebf\u7f8e\u5143\u5de8\u8d44\uff0c\u6536\u8d2dMedarex\u516c\u53f8\uff0c\u83b7\u5f97\u4e86\u672c\u5eb6\u4f51\u7684PD-1\u4e13\u5229\u72ec\u5bb6\u4f7f\u7528\u6743\uff0c\u5e76\u4ece\u5c0f\u91ce\u5236\u836f\u62ff\u56de\u4e86PD-1\u6291\u5236\u5242\u7684\u6240\u6709\u5546\u4e1a\u6743\u76ca\u3002<\/p>\n

BMS\u5f53\u65f6\u6b63\u4e13\u6ce8\u4e8e\u521b\u65b0\u751f\u7269\u836f\u7684\u7814\u7a76\uff0c\u91cd\u70b9\u5173\u6ce8\u80bf\u7624\u3001\u514d\u75ab\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u7b49\u75be\u75c5\u9886\u57df\uff0c\u5236\u6210\u4e86\u5168\u7403\u7b2c\u4e00\u4e2a\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u836f\u7269\u2014\u2014CTLA-4\u6291\u5236\u5242\u4f0a\u5339\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08Ipilimumab\uff09\uff0c\u57282011\u5e74\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff08\u5c1a\u672a\u5728\u4e2d\u56fd\u4e0a\u5e02\uff09\u3002\u5de7\u5408\u7684\u662f\uff0c1990\u5e74\u4ee3\uff0c\u9648\u5217\u5e73\u5c31\u53d7\u8058\u4e8eBMS\uff0c\u4ece\u4e8b\u4e867\u5e74\u7684\u7814\u7a76\u5de5\u4f5c\u3002<\/p>\n

BMS\u91cd\u91d1\u62bc\u6ce8\uff0cPD-1\u6291\u5236\u5242\u7684\u4e34\u5e8a\u6570\u636e\u5f88\u5feb\u8fce\u6765\u8f6c\u6298\u3002<\/p>\n

\u4e00\u5e74\u540e\uff0cBMS\u516c\u5e03\u9996\u6279\u60a3\u8005\u7ed3\u679c\uff0c\u90e8\u5206\u60a3\u8005\u7684\u80bf\u7624\u5b9e\u73b0\u4e86\u5b8c\u5168\u7f13\u89e3\uff08\u80bf\u7624\u4ee5\u53ca\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u5b8c\u5168\u6d88\u5931\uff09\u3001\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u4f53\u79ef\u663e\u8457\u7f29\u5c0f\uff0c\u4e14\u4e34\u5e8a\u75c7\u72b6\u3001\u4f53\u5f81\u5f97\u5230\u663e\u8457\u7f13\u89e3\uff09\uff0c\u4eba\u4eec\u624d\u610f\u8bc6\u5230\uff0c\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u8bc4\u4ef7\uff0c\u8981\u505a\u957f\u671f\u8ddf\u8e2a\uff0cPD-1\u6291\u5236\u5242\u7684\u5f00\u53d1\u91cd\u83b7\u91cd\u89c6\uff0c\u7814\u53d1\u8fc5\u901f\u63a8\u8fdb\u3002<\/p>\n

2014\u5e747\u6708\uff0c\u201cO\u836f\u201d\u6b27\u72c4\u6c83\u6b63\u5f0f\u83b7\u6279\uff0c\u6210\u4e3a\u4e86\u5168\u7403\u9996\u4e2aPD-1\u6291\u5236\u5242\uff0c\u6b64\u540e6\u5e74\uff0c\u5728\u5168\u7403\u8d85\u8fc765\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u6279\u4e8611\u4e2a\u7624\u79cd\uff0c\u6db5\u76d6\u80ba\u764c\u3001\u5934\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u809d\u764c\u3001\u80be\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u7b49\u5e38\u89c1\u764c\u79cd\u3002<\/p>\n

BMS\u6536\u83b7\u4e86\u5de8\u989d\u56de\u62a5\u30022015\u5e74\uff0cO\u836f\u7684\u5168\u7403\u9500\u552e\u989d\u5c31\u8fbe\u52309.42\u4ebf\u7f8e\u5143\uff0c2016\u5e74\u9500\u552e\u8e7f\u5347\u81f337.74\u4ebf\u7f8e\u5143\uff0c\u6b64\u540e\u4e09\u5e74\u6301\u7eed\u5927\u5356\uff0c2019\u5e74\u5750\u653672.04\u4ebf\u7f8e\u5143\uff0c\u5408\u4eba\u6c11\u5e01\u8d85\u8fc7500\u4ebf\u5143\uff0c\u5df2\u6210BMS\u8425\u6536\u4e3b\u529b\uff0c\u5e76\u8fc5\u901f\u6324\u8fdb\u5168\u7403\u80bf\u7624\u836f\u9500\u91cfTop 5\u3002<\/p>\n


\n<\/center>
\n2018\u5e74\uff0c\u672c\u5eb6\u4f51\u56e0\u201c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6cd5\u201d\u4e0a\u7684\u8d21\u732e\uff0c\u4e0e\u7f8e\u56fd\u514d\u75ab\u5b66\u5bb6\u8a79\u59c6\u65af•\u827e\u5229\u68ee\uff08James Allison\uff09\u4e00\u8d77\uff0c\u5206\u4eab\u4e86\u5f53\u5e74\u7684\u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u3002\u5f88\u591a\u4e1a\u5185\u4eba\u58eb\u8ba4\u4e3a\uff0c\u9648\u5217\u5e73\u4e5f\u5e94\u83b7\u5956\u3002
\n
\n\u9002\u5e94\u75c7\u5e7f\uff0c\u4e00\u5e7444\u4e07<\/b><\/p>\n

\u201cO\u836f\u201d\u6ca1\u6709\u8ba9\u4e2d\u56fd\u60a3\u8005\u7b49\u592a\u4e45\u3002<\/p>\n

\u201c2017\u5e7411\u6708\uff0c\u6211\u4eec\u5c31\u5411\u5f53\u65f6\u4e2d\u56fd\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\uff0c12\u6708\u88ab\u6388\u4e88\u4e86\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002\u201d\u9648\u601d\u6e0a\u8bf4\u3002<\/p>\n

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<\/p>\n

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\n<\/center>
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