{"id":13933,"date":"2020-06-08T00:00:00","date_gmt":"2020-06-07T16:00:00","guid":{"rendered":"http:\/\/15.134.89.131\/archive\/2020\/06\/08\/%e5%9b%bd%e4%ba%a7%e6%8a%97%e7%99%8c%e7%a5%9e%e8%8d%af%e6%95%88%e6%9e%9c%e6%83%8a%e4%ba%ba%ef%bc%8c%e6%8e%a7%e5%88%b6%e7%8e%87%e8%be%be97-9%e7%bb%84%e5%9b%be\/"},"modified":"2020-06-08T00:00:00","modified_gmt":"2020-06-07T16:00:00","slug":"%e5%9b%bd%e4%ba%a7%e6%8a%97%e7%99%8c%e7%a5%9e%e8%8d%af%e6%95%88%e6%9e%9c%e6%83%8a%e4%ba%ba%ef%bc%8c%e6%8e%a7%e5%88%b6%e7%8e%87%e8%be%be97-9%e7%bb%84%e5%9b%be","status":"publish","type":"post","link":"http:\/\/15.134.89.131\/archive\/?p=13933","title":{"rendered":"\u56fd\u4ea7\u6297\u764c\u201c\u795e\u836f\u201d\u6548\u679c\u60ca\u4eba\uff0c\u63a7\u5236\u7387\u8fbe97.9%(\u7ec4\u56fe)"},"content":{"rendered":"

\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a<\/strong><\/p>\n

\n\u201c\u56fd\u4ea7\u6297\u764c\u836f\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\uff01\u201d<\/p>\n

\u4f34\u968f\u7740\u592e\u89c6\u65b0\u95fb\u7684\u62a5\u9053\uff0c\u6297\u764c\u836f\u8fbe\u4f2f\u8212\u8fdb\u5165\u4e86\u8001\u767e\u59d3\u7684\u89c6\u91ce\u3002\u8fbe\u4f2f\u8212\u662f\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u6297\u80bf\u76241\u7c7b\u521b\u65b0\u836f\uff0c\u76ee\u524d\u5df2\u901a\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u83b7\u51c6\u4e0a\u5e02\uff0c\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n

<\/p>\n

\n\u56fd\u4ea7\u65b0\u6297\u764c\u836f\u8fbe\u4f2f\u8212\u662f\u4ec0\u4e48\uff1f<\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u7814\u53d1\u4e00\u79cd\u65b0\u836f\u662f\u5f88\u8270\u96be\u7684\uff0c\u8fc7\u7a0b\u6781\u5176\u590d\u6742\u800c\u4e14\u9700\u8981\u82b1\u8d39\u5927\u91cf\u7684\u65f6\u95f4\u3001\u8d22\u529b\u3001\u4eba\u529b\uff0c\u4f46\u4e00\u65e6\u7814\u53d1\u6210\u529f\uff0c\u5176\u610f\u4e49\u4e0d\u8a00\u800c\u55bb\uff0c\u800c\u8fbe\u4f2f\u8212\u5c31\u662f\u7b2c\u4e00\u4e2a\u7531\u4e2d\u56fd(\u4fe1\u8fbe\u751f\u7269\u548c\u56fd\u9645\u5236\u836f\u5927boss\u793c\u6765\u516c\u53f8\u5408\u4f5c)\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u79cd\u6297\u764c\u836f\u7269(\u8fc7\u5f80\u4e3b\u8981\u4ee5\u4eff\u5236\u4e3a\u4e3b)\u3002\u5b83\u7684\u4e0a\u5e02\u610f\u5473\u7740\u6211\u56fd\u5728\u6297\u764c\u836f\u7269\u4e0a\u5df2\u7ecf\u4ece\u4ee5\u4eff\u5236\u4e3a\u4e3b\uff0c\u8f6c\u5411\u521b\u65b0\uff0c\u8fdb\u5165\u56fd\u9645\u6297\u764c\u836f\u521b\u65b0\u7684\u7b2c\u4e00\u68af\u961f\u3002<\/p>\n

\u76ee\u524d\uff0c\u8fbe\u4f2f\u8212\u901a\u8fc7\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7684\u7b2c\u4e00\u4e2a\u75be\u75c5\u662f\u590d\u53d1\/\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u4e14\u5176\u4e34\u5e8a\u7814\u7a76ORIENT-1\u7ed3\u679c\u767b\u4e0a\u4e86\u300a\u67f3\u53f6\u5200\u00b7\u8840\u6db2\u5b66\u300b\u6742\u5fd7\u5c01\u9762\u3002<\/p>\n

<\/p>\n

\u8fbe\u4f2f\u8212\u4e3b\u8981\u901a\u8fc7\u7ed3\u5408\u60a3\u8005T\u7ec6\u80de\u8868\u9762\u7684PD-1\uff0c\u963b\u65adPD-1\u4e0ePD-L1\u548cPD-L2\u7684\u7ed3\u5408\uff0c\u5728\u89e3\u9664\u514d\u75ab\u6291\u5236\u6548\u5e94\u7684\u540c\u65f6\u6fc0\u6d3b\u514d\u75abT\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002<\/p>\n

\u770b\u5230\u8fd9\uff0c\u522b\u4ee5\u4e3a\u8fbe\u4f2f\u8212\u53ea\u80fd\u6cbb\u7597\u6dcb\u5df4\u7624\u4e00\u79cd\u75be\u75c5\uff0c\u5176\u5b83\u768420\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u5728\u8fc5\u901f\u7684\u63a8\u8fdb\u4e86\uff0c\u5305\u62ec\u4e00\u7ebf\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e00\/\u4e8c\u7ebf\u80ba\u9cde\u764c\u3001\u4e00\u7ebf\u80c3\u764c\u3001\u4e00\u7ebf\u809d\u764c\u3001\u4e00\/\u4e8c\u7ebf\u98df\u7ba1\u764c\u7b49\u3002<\/p>\n

\u76f8\u4fe1\u4e0d\u4e45\u7684\u5c06\u6765\uff0c\u5c31\u53ef\u4ee5\u542c\u5230\u83b7\u6279\u7684\u597d\u6d88\u606f\u4e86\u3002<\/p>\n

\u8fbe\u4f2f\u8212\u6709\u4f55\u201c\u795e\u5947\u201d\u4e4b\u5904\uff1f<\/p>\n

\u6dcb\u5df4\u7624\u5927\u5bb6\u5e94\u8be5\u6709\u542c\u8fc7\uff0c\u53d1\u75c5\u7387\u5e76\u4e0d\u4f4e\uff0c\u4f4d\u5c45\u6211\u56fd\u5e38\u89c1\u6076\u6027\u80bf\u7624\u53d1\u75c5\u7387\u7b2c8\u4f4d\uff0c\u8fd9\u51e0\u5e74\u8fd8\u6709\u201c\u4e0a\u4f4d\u201d\u8d8b\u52bf\u3002<\/p>\n

\u867d\u7136\u8bf4\u7ecf\u8fc7\u653e\u7597\u3001\u5316\u7597\u7b49\u4e00\u7ebf\u6cbb\u7597\u540e\uff0c\u6dcb\u5df4\u764c\u7684\u6cbb\u7597\u6548\u679c\u8fd8\u662f\u6bd4\u8f83\u7406\u60f3(\u591a\u6570\u53ef\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108)\uff0c\u4f46\u662f\u4ecd\u6709\u4e00\u90e8\u5206\u60a3\u8005\u4e3a\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624(cHL)\uff0c\u8fd9\u7c7b\u60a3\u8005\u5982\u679c\u7ecf\u8fc7\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u5931\u8d25\u540e\uff0c\u5e73\u5747\u5b58\u6d3b\u671f\u53ea\u67091-2\u5e74\u5de6\u53f3\u3002\u6240\u4ee5\uff0c\u4e4b\u524dcHL\u4e00\u76f4\u662f\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u96be\u9898\u4e4b\u4e00\uff0c\u540e\u6765\u7814\u7a76\u53d1\u73b0\uff0cPD-1\u6297\u4f53\u836f\u7269\u53ef\u4ee5\u663e\u8457\u5ef6\u957f\u548c\u6539\u5584\u60a3\u8005\u7684\u751f\u5b58\u3002\u800c\u8fbe\u4f2f\u8212\u5c31\u662fPD-1\/PD-L1\u6291\u5236\u5242\u7684\u4e00\u79cd\uff0c\u5bf9\u8fd9\u79cd\u6dcb\u5df4\u7624\u4e5f\u6709\u7740\u660e\u663e\u7684\u7597\u6548\u3002<\/p>\n

\u672c\u7740\u8ba9\u5927\u5bb6\u66f4\u52a0\u76f4\u63a5\u4e86\u89e3\u3001\u4fe1\u670d\u7684\u76ee\u7684\uff0c\u6211\u4eec\u76f4\u63a5\u7528\u6570\u636e\u6765\u8bf4\u8bdd\u3002<\/p>\n

\u8fd9\u9879\u4e34\u5e8a\u5b9e\u9a8c\uff08\u4ee3\u53f7ORIENT-1\uff09\u53ef\u4ee5\u8bf4\u662f\u6211\u56fd\u76ee\u524d\u9488\u5bf9cHL\u5165\u7ec4\u4eba\u6570\u6700\u591a\u7684\u7814\u7a76\uff0c\u4e00\u5171\u6536\u96c6\u4e8696\u4f4d\u653e\u7597\u4e0eASCT\u5728\u5185\u7684\u22652\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u4e2d\u56fdcHL\u60a3\u8005\uff0c\u7136\u540e\u7ed9\u8fd9\u4e9b\u60a3\u8005\u90fd\u4f7f\u7528\u4e86\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u6cbb\u7597\uff0c\u5242\u91cf200mg\uff0c\u4e09\u5468\u4e00\u6b21\u3002<\/p>\n

\u7ecf\u8fc7IRRC\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\u8bc4\u4f30\u5f97\u51fa\uff1a96\u4f4d\u60a3\u8005\u4e2d\u670974\u4f4d\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u80bf\u7624\u7684\u4f53\u79ef\u660e\u663e\u53d8\u5c0f\u4e86\uff0c\u8fbe\u5230\u5ba2\u89c2\u7f13\u89e3\u7684\u6807\u51c6\uff0c\u5176\u7f13\u89e3\u7387\u8fbe\u523080.4%\uff0c\u800c\u5176\u4e2d\u6709\u5c06\u8fd133.7%\u7684\u60a3\u8005\u80bf\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u75be\u75c5\u63a7\u5236\u7387(DCR)\u4e3a97.9%\u3002<\/p>\n

\u7531\u6b64\u6211\u4eec\u53ef\u4ee5\u770b\u51fa\u8fbe\u4f2f\u8212\u7684\u5389\u5bb3\u4e4b\u5904\uff0c\u53ea\u8981\u5408\u7406\u5229\u7528\uff0c\u76f8\u4fe1\u53ef\u4ee5\u5f88\u597d\u7684\u5e2e\u5230\u764c\u75c7\u60a3\u8005\u3002<\/p>\n

\u8fbe\u4f2f\u8212\u6cbb\u7597\u9700\u8981\u591a\u5c11\u94b1\uff1f<\/p>\n

PD-1\u6291\u5236\u5242\uff0c\u5728\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u5f53\u4e2d\u90fd\u8d77\u5230\u4e86\u975e\u5e38\u5173\u952e\u7684\u4f5c\u7528\uff0c\u5408\u7406\u89c4\u8303\u4f7f\u7528\uff0c\u53ef\u5e2e\u52a9\u60a3\u8005\u5b9e\u73b0\u957f\u671f\u751f\u5b58\uff0c\u751a\u81f3\u662f\u4e34\u5e8a\u6cbb\u6108\uff0c\u4f46\u662f\uff0c\u4ef7\u683c\u591a\u662f\u6bd4\u8f83\u9ad8\u7684\u3002\u800c\u8fbe\u4f2f\u8212\u4f5c\u4e3a\u5176\u4e2d\u4e00\u79cd\uff0c\u5176\u4ef7\u683c\u81ea\u7136\u4e5f\u662f\u5907\u53d7\u5173\u6ce8\u3002<\/p>\n

\u636e\u53ef\u9760\u6d88\u606f\uff0c\u8fbe\u4f2f\u8212\u5728\u6211\u56fd\u7684\u552e\u5356\u4ef7\u683c\u4e3a7838\u5143\/100mg\uff0c\u8fd9\u5355\u770b\u5f88\u591a\u4eba\u53ef\u80fd\u8fd8\u662f\u89c9\u5f97\u5f88\u8d35\uff0c\u4f46\u662f\u5982\u679c\u4f60\u62ff\u5b83\u548c\u8fdb\u53e3\u836f\u76f8\u6bd4\uff0c\u6bd4\u5982\u5e15\u535a\u5229\u73e0\u5355\u6297(\u4ef7\u683c\u572817000-18000\u5143\/100mg\u5de6\u53f3)\uff0c\u4f60\u4f1a\u53d1\u73b0\u8fbe\u4f2f\u8212\u7684\u4ef7\u683c\u5b9e\u5728\u662f\u592a\u4eb2\u6c11\u4e86\uff0c\u5c06\u8fd14\u6298\u5de6\u53f3\u3002<\/p>\n

\u4e0d\u4ec5\u5982\u6b64\uff0c\u6839\u636e\u6700\u65b0\u6d88\u606f\uff0c\u8fbe\u4f2f\u8212\u8fd8\u4f1a\u4f5c\u4e3a\u552f\u4e00\u7eb3\u5165\u533b\u4fdd\u7684PD1\/PD-L1\u836f\u7269\uff0c\u76ee\u524d\u5df2\u7ecf\u5f00\u59cb\u6267\u884c\u62a5\u9500\u4e86\uff0c\u53ea\u8981\u7b26\u5408\u62a5\u9500\u6761\u4ef6\u7684\u60a3\u8005\u5747\u53ef\u62a5\u9500\uff0c\u62a5\u9500\u540e\u60a3\u8005\u6240\u8981\u81ea\u8d39\u7684\u4ef7\u683c\u4ec5\u4ec5\u662f\u539f\u672c\u4ef7\u683c\u768410%\uff5e50%\uff0c\u6781\u5927\u7a0b\u5ea6\u4e0a\u7684\u51cf\u5c11\u4e86\u60a3\u8005\u7684\u7ecf\u6d4e\u538b\u529b\u3002<\/p>\n

\u4e00\u822c\u6765\u8bf4\uff0c\u60a3\u8005\u521d\u6b65\u8bc4\u4f30\u65f6\u95f4\u9700\u89816-9\u5468\uff0c\u6211\u4eec\u8fd9\u4ee56\u5468\u7684\u6cbb\u7597\u8d39\u4e3a\u4f7f\u7528\u514d\u75ab\u6cbb\u7597\u7684\u95e8\u69db\u8d39\u7528\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u7684\u201c\u95e8\u69db\u8d39\u7528\u201d\u4ec5\u4e3a1.14\u4e07\u5143\u3002<\/p>\n

\u968f\u7740\u533b\u5b66\u7684\u8fdb\u6b65\uff0c\u4ee5\u53ca\u66f4\u591a\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u7684\u5f00\u5c55\uff0c\u76f8\u4fe1\u672a\u6765\u8fd8\u4f1a\u6709\u66f4\u591a\u7684\u7531\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u836f\u7269\u51fa\u73b0\uff0c\u8ba9\u4e2d\u56fd\u53ef\u4ee5\u5728\u5168\u7403\u533b\u5b66\u821e\u53f0\u4e0a\u53d1\u51fa\u66f4\u54cd\u4eae\u7684\u2018\u4e2d\u56fd\u521b\u65b0\u4e4b\u58f0\u2019\uff01<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1]\u300a\u4e2d\u56fd\u521b\u65b0PD-1\u6291\u5236\u5242\u8fbe\u4f2f\u8212\u6b63\u5f0f\u767b\u9646\u56fd\u5185\u5e02\u573a\uff01\u300b.\u5065\u5eb7\u65f6\u62a5\u7f51.2019-02-22<\/p>\n

[2]\u300a\u8fbe\u4f2f\u8212\u88ab\u7eb3\u5165\u533b\u4fdd PD1\u514d\u75ab\u6cbb\u7597\u4e0d\u518d\u6602\u8d35\u300b.\u65b0\u6d6a\u533b\u836f\u65b0\u95fb.2020-04-26<\/p>\n

[3]\u300a\u5185\u5e55\uff01\u4fe1\u8fbe\u751f\u7269PD-1\u5355\u6297\u8fbe\u4f2f\u8212®\u4ef7\u683c\u516c\u5f00\uff1a\u56fd\u9645\u54c1\u8d28 \u4eb2\u6c11\u4ef7\u683c\u300b.\u65b0\u6d6a\u533b\u836f\u65b0\u95fb.2019-03-05<\/p>\n

[4]\u300a\u4e2d\u56fdPD-1\u6291\u5236\u5242\u6297\u764c\u521b\u65b0\u836f\u8fbe\u4f2f\u8212\u4e0a\u5e02\uff0c\u4e34\u5e8a\u7597\u6548\u5ab2\u7f8e\u201cO\u836f\u201d\u548c\u201cK\u836f\u201d\u300b. \u4e16\u754c\u533b\u7597\u79d1\u6280\u8d44\u8baf .2019-02-24<\/p>\n

[5]\u300a\u552f\u4e00\u533b\u4fddPD1\/PD-1\u836f\u7269\u8fbe\u4f2f\u8212\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u516c\u5e03\u6709\u671b\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u300b.\u751f\u6d3b\u89c2\u5bdf\u8303.2020-04-17<\/p>\n","protected":false},"excerpt":{"rendered":"

\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a \u201c\u56fd\u4ea7\u6297\u764c\u836f\u8fc8\u51fa\u4e86\u91cd\u8981\u7684 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14],"tags":[],"class_list":["post-13933","post","type-post","status-publish","format-standard","hentry","category-health"],"_links":{"self":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13933"}],"version-history":[{"count":0,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13933\/revisions"}],"wp:attachment":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13933"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}