{"id":13965,"date":"2020-09-09T00:00:00","date_gmt":"2020-09-08T16:00:00","guid":{"rendered":"http:\/\/15.134.89.131\/archive\/2020\/09\/09\/%e4%bb%a5%e6%af%92%e6%94%bb%e6%af%92%e8%9c%9c%e8%9c%82%e6%af%92%e7%b4%a0%e5%8f%aa%e9%9c%8060%e5%88%86%e9%92%9f%e5%8d%b3%e5%8f%af100%e6%9d%80%e6%ad%bb%e7%99%8c%e7%bb%86%e8%83%9e\/"},"modified":"2020-09-09T00:00:00","modified_gmt":"2020-09-08T16:00:00","slug":"%e4%bb%a5%e6%af%92%e6%94%bb%e6%af%92%e8%9c%9c%e8%9c%82%e6%af%92%e7%b4%a0%e5%8f%aa%e9%9c%8060%e5%88%86%e9%92%9f%e5%8d%b3%e5%8f%af100%e6%9d%80%e6%ad%bb%e7%99%8c%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"http:\/\/15.134.89.131\/archive\/?p=13965","title":{"rendered":"\u4ee5\u6bd2\u653b\u6bd2!\u871c\u8702\u6bd2\u7d20\u53ea\u970060\u5206\u949f\u5373\u53ef100%\u6740\u6b7b\u764c\u7ec6\u80de"},"content":{"rendered":"<p style=\"color: #666; font-size: 14px; margin-bottom: 15px;\">\ud83d\udc49 <strong>\u672c\u6587\u4f5c\u8005\uff1a<\/strong><\/p>\n<hr style=\"border: 0; border-top: 1px dashed #ddd; margin-bottom: 20px;\" \/>\n\u201c\u4ee5\u6bd2\u653b\u6bd2\u201d\u7684\u8bf4\u6cd5\u7531\u6765\u5df2\u4e45\uff0c\u4f8b\u5982\u6628\u65e5\u516c\u5e03\u76842020\u672a\u6765\u79d1\u5b66\u5927\u5956\u751f\u547d\u79d1\u5b66\u5956\uff0c\u83b7\u5956\u8005\u5f20\u4ead\u680b\u6b63\u662f\u5229\u7528\u7812\u971c\u6210\u529f\u6cbb\u6108\u4e86\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/p>\n<p>\u67d0\u4e9b\u6bd2\u6027\u8f83\u5927\u7684\u836f\u7269\u5728\u7279\u5b9a\u60c5\u51b5\u4e0b\u4f1a\u53d1\u6325\u663e\u8457\u7684\u6cbb\u7597\u4f5c\u7528\uff0c\u56e0\u6b64\uff0c\u5728\u4fdd\u8bc1\u7528\u836f\u5b89\u5168\u7684\u524d\u63d0\u4e0b\uff0c\u9002\u91cf\u4f7f\u7528\u6709\u6bd2\u836f\u7269\u6765\u6cbb\u6108\u4e00\u4e9b\u987d\u75be\u4e0d\u5931\u4e3a\u4e00\u79cd\u884c\u4e4b\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8702\u6bd2\u2014\u2014\u8fd9\u79cd\u5f88\u5e38\u89c1\u7684\u6bd2\u6027\u7269\u8d28\uff0c\u65e0\u8bba\u662f\u4f20\u7edf\u533b\u5b66\u8fd8\u662f\u73b0\u4ee3\u533b\u5b66\uff0c\u90fd\u8868\u660e\u8702\u6bd2\u5bf9\u4e00\u4e9b\u75c5\u75c7\u5177\u6709\u5947\u7279\u7684\u7597\u6548\uff0c\u8bf8\u5982\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u75db\u98ce\u548c\u504f\u5934\u75db\u7b49\u3002\u66f4\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u8fd1\u5e74\u6765\uff0c\u6709\u7814\u7a76\u8868\u660e\u8702\u6bd2\u8fd8\u53ef\u4ee5\u9ad8\u6548\u6740\u4f24\u764c\u7ec6\u80de\uff0c\u6216\u53ef\u6210\u4e3a\u6cbb\u7597\u764c\u75c7\u7684\u6f5c\u5728\u836f\u7269\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u897f\u6fb3\u5927\u5229\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5728 Nature \u65d7\u4e0b\u671f\u520a npj Precision Oncology \u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\uff1aHoneybee<br \/>\nvenom and melittin suppress growth factor receptor activation in<br \/>\nHER2-enriched and triple-negative breast cancer \u7684\u7814\u7a76\u8bba\u6587\u3002<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u8c03\u67e5\u4e86\u8702\u6bd2\u4ee5\u53ca\u4e00\u79cd\u540d\u4e3a\u201c\u8702\u6bd2\u7d20\u201d\u7684\u6210\u5206\u5316\u5408\u7269\u5bf9\u4e0d\u540c\u7c7b\u578b\u4e73\u817a\u764c\u7ec6\u80de\u7684\u6297\u764c\u7279\u6027\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8702\u6bd2\u80fd\u591f\u6709\u6548\u8bf1\u5bfc\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u7279\u522b\u662f\u5728\u4fb5\u88ad\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u4ee5\u53caHER2\u5bcc\u96c6\u7684\u4e73\u817a\u764c\u4e9a\u578b\u4e2d\u6740\u4f24\u80fd\u529b\u63a5\u8fd1100%\uff0c\u4e14\u5bf9\u6b63\u5e38\u7ec6\u80de\u5f71\u54cd\u6781\u5c0f\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/web.popo8.com\/202009\/09\/4\/1e73667d26.jpg\"><\/p>\n<p>\n\u5b9e\u9645\u4e0a\uff0c\u65e9\u57281950\u5e74\uff0c\u4e00\u7bc7\u53d1\u8868\u5728 Nature \u4e0a\u7684\u8bba\u6587\u4fbf\u62a5\u9053\u4e86\u8702\u6bd2\u53ef\u4ee5\u51cf\u5c11\u690d\u7269\u4e2d\u7684\u80bf\u7624\u7684\u751f\u957f\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u5df2\u7ecf\u8fc7\u53bb\u4e86\u6570\u5341\u5e74\uff0c\u8702\u6bd2\u4f5c\u4e3a\u6297\u764c\u7269\u8d28\u7684\u5177\u4f53\u5206\u5b50\u673a\u5236\u548c\u9776\u5411\u6027\u95ee\u9898\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ecd\u7136\u662f\u672a\u77e5\u7684\u3002<\/p>\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u4e73\u817a\u764c\uff08breast cancer\uff09\u662f\u4e00\u7c7b\u56e0\u4e73\u817a\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u5931\u63a7\u800c\u5bfc\u81f4\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u53d1\u75c5\u7387\u5e38\u5e74\u4f4d\u5c45\u5973\u6027\u6076\u6027\u80bf\u7624\u9996\u4f4d\uff0c\u6240\u4ee5\u5b83\u4e5f\u88ab\u5e38\u79f0\u4e3a\u201c\u7c89\u7ea2\u6740\u624b\u201d\uff01\u56e0\u6b64\uff0c\u5f00\u53d1\u9488\u5bf9\u4e73\u817a\u764c\u7684\u65b0\u7597\u6cd5\u662f\u5341\u5206\u5177\u6709\u610f\u4e49\u7684\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005 Ciara Duffy \u535a\u58eb\u8868\u793a\uff0c\u4e4b\u524d\u6ca1\u6709\u4eba\u6bd4\u8f83\u8fc7\u8702\u6bd2\u6216\u8702\u6bd2\u7d20\u5bf9\u6240\u6709\u4e0d\u540c\u4e9a\u578b\u4e73\u817a\u764c\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u56e0\u6b64\uff0c\u4ed6\u4eec\u5728\u6b63\u5e38\u4e73\u817a\u7ec6\u80de\u548c\u4e73\u817a\u764c\u4e34\u5e8a\u4e9a\u578b\u7ec6\u80de\u4e0a\u6d4b\u8bd5\u4e86\u8702\u6bd2\u7684\u6cbb\u7597\u6548\u679c\u3002\u201d<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c\u8702\u6bd2\u53ef\u4ee5\u663e\u8457\u5730\u3001\u9009\u62e9\u6027\u5730\u3001\u5feb\u901f\u5730\u6740\u4f24\u4e09\u9634\u6027\u4e73\u817a\u764c\u7ec6\u80de\u548c\u5bcc\u542bHER2\u7684\u4e73\u817a\u764c\u7ec6\u80de\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7279\u5b9a\u6d53\u5ea6\u7684\u8702\u6bd2\u5728\u8bf1\u5bfc100%\u7684\u764c\u7ec6\u80de\u6b7b\u4ea1\u7684\u540c\u65f6\uff0c\u800c\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u5f71\u54cd\u6781\u5c0f\u3002<\/p>\n<p>\u5bf9\u6b64\uff0cCiara Duffy&nbsp;\u535a\u58eb\u8868\u793a\uff1a\u201c\u8fd9\u79cd\u6bd2\u6db2\u975e\u5e38\u6709\u6548\uff01\u201d<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/web.popo8.com\/202009\/09\/2\/e759b24a42.jpg\"><\/p>\n<p>\u8702\u6bd2\u6536\u96c6\u548c\u8702\u6bd2\u7d20\u6cbb\u7597\u4e73\u817a\u764c\u7ec6\u80de\u7684\u8fc7\u7a0b<\/p>\n<p>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8702\u6bd2\u7d20\uff08melittin\uff0c\u4e5f\u79f0\u8702\u6bd2\u80bd\uff09\u662f\u8702\u6bd2\u4e2d\u7684\u6709\u6548\u6210\u5206\uff0c\u5b83\u662f\u4e00\u79cd\u975e\u5e38\u5c0f\u7684\u3001\u5e26\u6b63\u7535\u8377\u7684\u591a\u80bd\uff0c\u800c\u8fd9\u79cd\u591a\u80bd\u53ef\u4ee5\u901a\u8fc7\u5316\u5b66\u5408\u6210\u7684\u65b9\u5f0f\u83b7\u5f97\uff0c\u5e76\u4e14\u8fd9\u79cd\u5408\u6210\u4ea7\u7269\u4e0e\u8702\u6bd2\u7684\u5927\u90e8\u5206\u6297\u764c\u6548\u679c\u76f8\u540c\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/web.popo8.com\/202009\/09\/3\/3c29e6f49f.jpg\"><\/p>\n<p>\u8702\u6bd2\u548c\u8702\u6bd2\u7d20\u7684\u6700\u5927\u534a\u6291\u5236\u6d53\u5ea6(IC50s)<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8702\u6bd2\u7d20\u53ef\u4ee5\u572860\u5206\u949f\u5185\u5b8c\u5168\u7834\u574f\u764c\u7ec6\u80de\u7ec6\u80de\u819c\uff0c\u5e76\u4e14\u5728\u572820\u5206\u949f\u5185\uff0c\u8702\u6bd2\u7d20\u5c31\u80fd\u963b\u65ad\u764c\u7ec6\u80de\u7684\u5316\u5b66\u4fe1\u606f\u2014\u2014\u5e72\u6270\u4e73\u817a\u764c\u7ec6\u80de\u8d28\u819c\u4e2dEGFR\u548cHER2\u53d7\u4f53\u7684\u78f7\u9178\u5316\u6765\u6291\u5236\u8fd9\u4e9b\u53d7\u4f53\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u6291\u5236\u764c\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u3002<\/p>\n<p>\u7528\u8702\u6bd2\u548c\u8702\u6bd2\u7d20\u5904\u7406SUM159\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790<\/p>\n<p>\u897f\u6fb3\u5927\u5229\u4e9a\u5927\u5b66Peter Klinken&nbsp;\u6559\u6388\u8868\u793a\uff0c\u201c\u8fd9\u662f\u4e00\u4e2a\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u4ee4\u4eba\u5174\u594b\u7684\u53d1\u73b0\uff0c\u8fd9\u9879\u7814\u7a76\u8bc1\u660e\u4e86\u8702\u6bd2\u7d20\u662f\u5982\u4f55\u5e72\u6270\u4e73\u817a\u764c\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u901a\u8def\u4ee5\u51cf\u5c11\u7ec6\u80de\u590d\u5236\u7684\uff0c\u5b83\u8868\u660e\u81ea\u7136\u754c\u7684\u5316\u5408\u7269\u662f\u53ef\u4ee5\u7528\u6765\u6cbb\u7597\u4eba\u7c7b\u75be\u75c5\u7684\u3002\u201d<\/p>\n<p>\u8fdb\u4e00\u6b65\u7684\u7a81\u53d8\u7814\u7a76\u8868\u660e\uff0c\u8702\u6bd2\u7d20\u5e26\u6b63\u7535\u8377\u7684C\u7aef\u5e8f\u5217\u4ecb\u5bfc\u4e86\u8d28\u819c\u76f8\u4e92\u4f5c\u7528\u548c\u6297\u764c\u6d3b\u6027\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u5bf9\u8702\u6bd2\u7d20\u7684RGD\u57fa\u5e8f\u8fdb\u884c\u5de5\u7a0b\u6539\u9020\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u8702\u6bd2\u7d20\u5bf9\u6076\u6027\u7ec6\u80de\u7684\u9776\u5411\u6027\uff0c\u4e14\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u6bd2\u6027\u6700\u5c0f\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/web.popo8.com\/202009\/09\/9\/872abab104.jpg\"><\/p>\n<p>\u8702\u6bd2\u7d20\u5e72\u6270\u8d28\u819cRTKs\u4e8c\u805a\u5316\u548c\u78f7\u9178\u5316\u7684\u4f5c\u7528\u6a21\u578b<\/p>\n<p>\u6700\u540e\uff0cCiara Duffy \u535a\u58eb\u8fd8\u6d4b\u8bd5\u4e86\u8702\u6bd2\u7d20\u662f\u5426\u53ef\u4ee5\u4e0e\u73b0\u6709\u7684\u5316\u7597\u836f\u7269\u4e00\u8d77\u4f7f\u7528\uff0c\u56e0\u4e3a\u5b83\u4f1a\u5728\u4e73\u817a\u764c\u7ec6\u80de\u819c\u4e0a\u7a7f\u5b54\uff0c\u4ece\u800c\u4f7f\u5f97\u5316\u7597\u836f\u7269\u8fdb\u5165\u764c\u7ec6\u80de\uff0c\u8bf1\u5bfc\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u5316\u7597\u836f\u7269\u591a\u70ef\u7d2b\u6749\u9187\uff08docetaxel\uff09\u4e0e\u8702\u6bd2\u7d20\u7684\u7ec4\u5408\u7597\u6cd5\u5728\u964d\u4f4e\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u65b9\u9762\u975e\u5e38\u6709\u6548\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/web.popo8.com\/202009\/09\/1\/018bdd61d0.jpg\"><\/p>\n<p>\u8702\u6bd2\u7d20\u8054\u5408\u591a\u70ef\u7d2b\u6749\u9187\u6cbb\u7597\u5c0f\u9f20\u80bf\u7624<\/p>\n<p>\u603b\u800c\u8a00\u4e4b\uff0c\u8702\u6bd2\u4f5c\u4e3a\u4e00\u79cd\u5929\u7136\u5316\u5408\u7269\uff0c\u5374\u51fa\u4e4e\u610f\u6599\u5730\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002\u8fd9\u9879\u7814\u7a76\u5728\u7ec6\u80de\u6c34\u5e73\u548c\u5c0f\u9f20\u6a21\u578b\u4e0a\u8bc1\u5b9e\u8702\u6bd2\u53ca\u8702\u6bd2\u7d20\u53ef\u4ee5\u6709\u6548\u6740\u4f24\u4e73\u817a\u764c\u7ec6\u80de\uff0c\u7279\u522b\u662f\u96be\u6cbb\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u4e14\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u5f71\u54cd\u6781\u5c0f\u3002<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u8fd8\u8868\u793a\uff0c\u4ed6\u4eec\u5c06\u7ee7\u7eed\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u4ee5\u6b63\u5f0f\u8bc4\u4f30\u9012\u9001\u8702\u6bd2\u7d20\u7684\u6700\u4f73\u65b9\u6cd5\uff0c\u4ee5\u53ca\u6bd2\u6027\u548c\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002<\/p>\n<p>\u8bba\u6587\u94fe\u63a5\uff1a<br \/>\nwww.nature.com\/articles\/s41698-020-00129-0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83d\udc49 \u672c\u6587\u4f5c\u8005\uff1a \u201c\u4ee5\u6bd2\u653b\u6bd2\u201d\u7684\u8bf4\u6cd5\u7531\u6765\u5df2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14],"tags":[],"class_list":["post-13965","post","type-post","status-publish","format-standard","hentry","category-health"],"_links":{"self":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13965"}],"version-history":[{"count":0,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=\/wp\/v2\/posts\/13965\/revisions"}],"wp:attachment":[{"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13965"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/15.134.89.131\/archive\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}